ArticleeLife2019
The recovery of standing and locomotion after spinal cord injury does not require task-specific training.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed.
- Biologically-constrained spiking neural network for neuromodulation in locomotor recovery after spinal cord injury.PLoS computational biology · 2026Article
- Recovery in gait and posture: a network-based approach to the assessment of rehabilitation effectiveness after spinal cord injury.Frontiers in network physiology · 2026Article
- Central Pattern Generators in Spinal Cord Injury: Mechanisms, Modulation, and Therapeutic Strategies for Motor Recovery.JOR spine · 2025Review
- Effects of spinal transection and locomotor speed on muscle synergies of the cat hindlimb.The Journal of physiology · 2025Article
- Disuse plasticity limits spinal cord injury recovery.iScience · 2025Article
- Development of a chronic compression spinal cord injury model in neonatal and adult rats.Animal models and experimental medicine · 2024Article
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- Spinal sensorimotor circuits play a prominent role in hindlimb locomotor recovery after staggered thoracic lateral hemisections but cannot restore posture and interlimb coordination during quadrupedal locomotion in adult cats.bioRxiv : the preprint server for biology · 2023Article
- Modulation of the gait pattern during split-belt locomotion after lateral spinal cord hemisection in adult cats.Journal of neurophysiology · 2022Article
- Control of Forelimb and Hindlimb Movements and Their Coordination during Quadrupedal Locomotion across Speeds in Adult Spinal Cats.Journal of neurotrauma · 2022Article
- State- and Condition-Dependent Modulation of the Hindlimb Locomotor Pattern in Intact and Spinal Cats Across Speeds.Frontiers in systems neuroscience · 2022Article
- Control of Mammalian Locomotion by Somatosensory Feedback.Comprehensive Physiology · 2021Article
- Effects of methylprednisolone and treadmill training on spinal cord injury in experimental rats.Experimental and therapeutic medicine · 2021Article
- Spinal Cord Injury-Induced Changes in Encoding and Decoding of Bipedal Walking by Motor Cortical Ensembles.Brain sciences · 2021Article
- Utility of somatosensory and motor-evoked potentials in reflecting gross and fine motor functions after unilateral cervical spinal cord contusion injury.Neural regeneration research · 2021Article
- The Spinal Control of Backward Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- A Validation of Supervised Deep Learning for Gait Analysis in the Cat.Frontiers in neuroinformatics · 2021Article
- Inhibition and Facilitation of the Spinal Locomotor Central Pattern Generator and Reflex Circuits by Somatosensory Feedback From the Lumbar and Perineal Regions After Spinal Cord Injury.Frontiers in neuroscience · 2021Review
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Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
After complete spinal cord injury, mammals, including mice, rats and cats, recover hindlimb locomotion with treadmill training. The premise is that sensory cues consistent with locomotion reorganize spinal sensorimotor circuits. Here, we show that hindlimb standing and locomotion recover after spinal transection in cats without task-specific training. Spinal-transected cats recovered full weight bearing standing and locomotion after five weeks of rhythmic manual stimulation of triceps surae muscles (non-specific training) and without any intervention. Moreover, cats modulated locomotor speed and performed split-belt locomotion six weeks after spinal transection, functions that were not trained or tested in the weeks prior. This indicates that spinal networks controlling standing and locomotion and their interactions with sensory feedback from the limbs remain largely intact after complete spinal cord injury. We conclude that standing and locomotor recovery is due to the return of neuronal excitability within spinal sensorimotor circuits that do not require task-specific activity-dependent plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.