Evidence map›Paper›PMID 31825144›Full record

Trial reportPediatric transplantation2020

Early changes in cell-free DNA levels in newly transplanted heart transplant patients.

Steven D Zangwill, Steven J Kindel, William S Ragalie, Paula E North, Alyssa Pollow, Mats Hidestrand, Aoy Tomita-Mitchell, Karl D Stamm, Michael E Mitchell

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatric transplantation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
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  8. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Steven D ZangwillDivision of Cardiology, Phoenix Children's Hospital, Phoenix, AZ, USA.ORCID 0000-0002-1838-4714
Steven J KindelDivision of Pediatric Cardiology, Medical College of Wisconsin, Herma Heart Institute, Children's Wisconsin, Milwaukee, WI, USA.
William S RagalieDivision of Cardiothoracic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Paula E NorthDepartment of Pathology, Medical College of Wisconsin, Children's Hospital of Wisconsin, Wauwatosa, WI, USA.
Alyssa PollowDivision of Pediatric Cardiology, Medical College of Wisconsin, Herma Heart Institute, Children's Wisconsin, Milwaukee, WI, USA.
Mats HidestrandDivision of Pediatric Cardiothoracic Surgery, Medical College of Wisconsin, Herma Heart Institute, Children's Wisconsin, Milwaukee, WI, USA.
Aoy Tomita-MitchellDivision of Pediatric Cardiothoracic Surgery, Medical College of Wisconsin, Herma Heart Institute, Children's Wisconsin, Milwaukee, WI, USA.
Karl D StammTai Diagnostics Inc., Wauwatosa, WI, USA.
Michael E MitchellDivision of Pediatric Cardiothoracic Surgery, Medical College of Wisconsin, Herma Heart Institute, Children's Wisconsin, Milwaukee, WI, USA.
Children's Hospital of Wisconsin · USNanoAffix Science (United States) · USPhoenix Children's Hospital · USUniversity of California, Los Angeles · US

Funding

Clinical and Translational Science AwardUL1TR001436 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI FREED, JULIE K · 2015 to 2025
$47.5M
Targeted, Highly Sensitive, Non-Invasive Cardiac Transplant Rejection MonitoringR01HL119747 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI MITCHELL, AOY TOMITA, MITCHELL, MICHAEL EDWARD · 2013 to 2017
$3.3M
NCATS NIH HHS UL1 TR001436NHLBI NIH HHS 5R01HL119747NHLBI NIH HHS R01 HL119747NIH HHS UL1TR001436
6 · The paper itself

Abstract

Heart transplantation is a well-established therapy for end-stage heart failure in children and young adults. The highest risk of graft loss occurs in the first 60 days post-transplant. Donor fraction of cell-free DNA is a highly sensitive marker of graft injury. Changes in cell-free DNA levels have not previously been studied in depth in patients early after heart transplant. A prospective study was conducted among heart transplant recipients at a single pediatric heart center. Blood samples were collected from children and young adult transplant patients at three time points within 10 days of transplantation. DF and total cell-free DNA levels were measured using a targeted method (myTAI

Indexed as

Heart TransplantationAdolescentBiomarkersCell-Free Nucleic AcidsChildChild, PreschoolFemaleFollow-Up StudiesGraft RejectionHeart FailureHumansInfantMalePilot ProjectsPostoperative PeriodProspective StudiesBiomarkersCell-Free Nucleic Acidsbiomarkerscell-free DNAearly postoperative periodpediatric heart transplant

Identifiers

PMID31825144
PMCPMC7065377
OpenAlexW2995479567

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.