ArticleThe EMBO journal2020
Legionella pneumophila regulates the activity of UBE2N by deamidase-mediated deubiquitination.
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Article in The EMBO journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
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Who cites it
39 citing papers in PubMed, 55 citations in OpenAlex.
- Crystal structure of Legionella pneumophila glycosidase effector LegY.Acta crystallographica. Section F, Structural biology communications · 2026Article
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- Molecular evolution and adaptations ofFrontiers in cellular and infection microbiology · 2026Review
- Internal Ubiquitin Electrophiles for Covalent Trapping and Inhibition of Deubiquitinases.Chembiochem : a European journal of chemical biology · 2025Article
- Regulation of host immunity by a novel Legionella pneumophila E3 ubiquitin ligase.PLoS pathogens · 2025Article
- Modulation of host ATP levels by secreted bacterial effectors.Nature communications · 2025Article
- Insights into mechanisms of ubiquitin ADP-ribosylation reversal.Biochemical Society transactions · 2024Review
- A comprehensive two-hybrid analysis to explore themSystems · 2024Article
- Legionella maintains host cell ubiquitin homeostasis by effectors with unique catalytic mechanisms.Nature communications · 2024Article
- Article
- Multi-tiered actions ofeLife · 2024Article
- Legionella maintains host cell ubiquitin homeostasis by effectors with unique catalytic mechanisms.Research square · 2024Article
- Microtubules provide force to promote membrane uncoating in vacuolar escape for a cyto-invasive bacterial pathogen.Nature communications · 2024Article
- Legionella pneumophila-mediated host posttranslational modifications.Journal of molecular cell biology · 2023Review
- Ubiquitin-targeted bacterial effectors: rule breakers of the ubiquitin system.The EMBO journal · 2023Review
- Mechanism and Modulation of SidE Family Proteins in the Pathogenesis ofPathogens (Basel, Switzerland) · 2023Review
- An expanded lexicon for the ubiquitin code.Nature reviews. Molecular cell biology · 2023Review
- Intracellular persister: A stealth agent recalcitrant to antibiotics.Frontiers in cellular and infection microbiology · 2023Review
- Ubiquitin-regulating effector proteins from Legionella.BMB reports · 2022Review
- Reversible modification of mitochondrial ADP/ATP translocases by pairedProceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Ninghai GanPurdue Institute for Inflammation, Immunology and Infectious Disease and Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.ORCID 0000-0001-7238-4056
Hongxin GuanProvincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, The Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, Key Laboratory of OptoElectronic Science and Technology for Medicine of the Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, China.
Yini HuangProvincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, The Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, Key Laboratory of OptoElectronic Science and Technology for Medicine of the Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, China.
Ting YuProvincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, The Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, Key Laboratory of OptoElectronic Science and Technology for Medicine of the Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, China.
Jiaqi FuPurdue Institute for Inflammation, Immunology and Infectious Disease and Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Ernesto S NakayasuBiological Science Division, Pacific Northwest National Laboratory, Richland, WA, USA.ORCID 0000-0002-4056-2695
Kedar PuvarDepartment of Chemistry, Purdue University, West Lafayette, IN, USA.ORCID 0000-0003-1788-2604
Chittaranjan DasDepartment of Chemistry, Purdue University, West Lafayette, IN, USA.
Dongmei WangProvincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, The Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, Key Laboratory of OptoElectronic Science and Technology for Medicine of the Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, China.
Songying OuyangProvincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, The Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, Key Laboratory of OptoElectronic Science and Technology for Medicine of the Ministry of Education, College of Life Sciences, Fujian Normal University, Fuzhou, China.ORCID 0000-0002-1120-1524
Zhao-Qing LuoPurdue Institute for Inflammation, Immunology and Infectious Disease and Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.ORCID 0000-0001-8890-6621
Fujian Normal University · CNPurdue University West Lafayette · USPacific Northwest National Laboratory · US
Funding
Mechanism of atypical ubiquitination and deubiquitination by bacterial effectorsR01GM126296 · NIGMS · PURDUE UNIVERSITY · PI Chittaranjan Das · 2018 to 2026
$3.6MEffector-mediated Ubiquitin Manipulation in Legionella Pneumophila PathogenesisR01AI127465 · NIAID · PURDUE UNIVERSITY · PI Qing Deng · 2017 to 2026
$3.4MCentral Government Guiding Local Science and Technology Development 2017L3009Fujian Normal University (FNU) Z0210509HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI127465HHS | NIH | National Institute of General Medical Sciences (NIGMS) R01GM126296NIAID NIH HHS R01 AI127465NIGMS NIH HHS R01 GM126296NSF | Foundation for Innovative Research Groups of the National Natural Science Foundation of China 31200559NSF | Foundation for Innovative Research Groups of the National Natural Science Foundation of China 31570875NSF | Foundation for Innovative Research Groups of the National Natural Science Foundation of China 31770948
Abstract
The Legionella pneumophila effector MavC induces ubiquitination of the E2 ubiquitin-conjugating enzyme UBE2N by transglutamination, thereby abolishing its function in the synthesis of K
Indexed as
Signal TransductionBacterial ProteinsHEK293 CellsHumansLegionella pneumophilaPolyubiquitinType IV Secretion SystemsUbiquitinUbiquitinationUbiquitin-Conjugating EnzymesBacterial ProteinsPolyubiquitinType IV Secretion SystemsUBE2N protein, humanUbiquitinUbiquitin-Conjugating EnzymesdeamidationimmunityNFκBtype IV secretionvirulence
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.