ReviewFrontiers in oncology2019
Susceptibility of Multiple Primary Cancers in Patients With Head and Neck Cancer: Nature or Nurture?
Review in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Pooled it
- Long-term survival in a case report with metachronous quadruple primary malignancies involving multiple organ systems.Discover oncology · 2026Article
- Personalized ctDNA analysis for detection of residual disease and recurrence in surgically treated HNSCC patients.NPJ precision oncology · 2026Article
- Lymphadenopathy in Concurrent Head and Neck Malignancies.Case reports in radiology · 2026Article
- Multiple primary cancers with gastrointestinal malignant tumors as the first manifestation: Three case reports and review of literature.World journal of gastroenterology · 2025Review
- Artificial Intelligence in Head and Neck Cancer: Innovations, Applications, and Future Directions.Current oncology (Toronto, Ont.) · 2024Review
- Genomic alterations in oral multiple primary cancers.International journal of oral science · 2024Article
- Providing Suggested Rules for Multiple Primary Cancer Recording, Coding and Registering in Population-based Cancer Registry.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Single-cell transcriptomic profiling for inferring tumor origin and mechanisms of therapeutic resistance.NPJ precision oncology · 2022Article
- Multiple primary squamous cell carcinomas of the oral cavity: A cross-sectional study in vietnam.Annals of medicine and surgery (2012) · 2022Article
- The kinesin Eg5 inhibitor K858 exerts antiproliferative and proapoptotic effects and attenuates the invasive potential of head and neck squamous carcinoma cells.Investigational new drugs · 2022Article
- Anti-Tumoral Effects of a (1Pharmaceuticals (Basel, Switzerland) · 2021Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple primary cancers (MPCs) are major obstacles to long-term survival in head and neck cancer (HNSCC), however, the molecular mechanism underlying multiple carcinogenesis remains unclear. "Field cancerization" is a classical theory to elaborate the malignant progression of MPCs. Apart from environmental and immune factors, genetic factors may have great potential as molecular markers for MPCs risk prediction. This review focuses on inherited and acquired gene mutations in MPCs, including germ-line mutation, single-nucleotide polymorphism, chromosomal instability, microsatellite instability and DNA methylation. And definition and prognosis of MPCs have also been discussed. These may pave the way for the early detection, prevention and effective treatment of MPCs in HNSCC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.