ArticleTissue engineering and regenerative medicine2019
Development of Macroporous Chitosan Scaffolds for Eyelid Tarsus Tissue Engineering.
Article in Tissue engineering and regenerative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- [Repair and reconstruction of facial organ injuries: a perfect fit of structure and function].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Review
- Functionalized chitosan-graphene magnetic nanocomposites enhance collagen synthesis in scleral fibroblasts.Open life sciences · 2026Article
- Investigation into the use of a chitosan scaffold for tarsal plate substitution in eyelid reconstruction.Regenerative biomaterials · 2025Article
- Biopolymeric Innovations in Ophthalmic Surgery: Enhancing Devices and Drug Delivery Systems.Polymers · 2024Review
- Towards Complex Tissues Replication: Multilayer Scaffold Integrating Biomimetic Nanohydroxyapatite/Chitosan Composites.Bioengineering (Basel, Switzerland) · 2024Article
- Polymers and Biomaterials for Posterior Lamella of the Eyelid and the Lacrimal System.Polymers · 2024Review
- Biomaterials and tissue engineering strategies for posterior lamellar eyelid reconstruction: Replacement or regeneration?Bioengineering & translational medicine · 2023Review
- Azithromycin-carrying and microtubule-orientated biomimetic poly (lactic-co-glycolic acid) scaffolds for eyelid reconstruction.Frontiers in medicine · 2023Article
- Gelatin and Chitosan as Meat By-Products and Their Recent Applications.Foods (Basel, Switzerland) · 2022Review
- Histochemical Comparison of Human and Rat Lacrimal Glands: Implications for Bio-Engineering Studies.Translational vision science & technology · 2022Article
- Advances in Injectable In Situ-Forming Hydrogels for Intratumoral Treatment.Pharmaceutics · 2021Review
- Review
- Graphene Hybrid Materials for Controlling Cellular Microenvironments.Materials (Basel, Switzerland) · 2020Review
- Characterization of a Bioresorbable Magnesium-Reinforced PLA-Integrated GTR/GBR Membrane as Dental Applications.Scanning · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Reconstruction of large eyelid defects remains challenging due to the lack of suitable eyelid tarsus tissue substitutes. We aimed to evaluate a novel bioengineered chitosan scaffold for use as an eyelid tarsus substitute. Methods: Three-dimensional macroporous chitosan hydrogel scaffold were produced via cryogelation with specific biomechanical properties designed to directly match characteristics of native eyelid tarsus tissue. Scaffolds were characterized by confocal microscopy and tensile mechanical testing. To optimise biocompatibility, human eyelid skin fibroblasts were cultured from biopsy-sized samples of fresh eyelid skin. Immunological and gene expression analysis including specific fibroblast-specific markers were used to determine the rate of fibroblast de-differentiation Results: The chitosan scaffolds were shown to support the attachment and proliferation of NIH 3T3 mouse fibroblasts and human orbital skin fibroblasts Conclusions: This bioengineered tissue has the potential to be used as a tarsus substitute during eyelid reconstruction, offering the opportunity to pre-seed the patient's own cells and represents a truly personalised approach to tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.