ArticleTissue engineering and regenerative medicine2019
Wound Healing Potential of Low Temperature Plasma in Human Primary Epidermal Keratinocytes.
Article in Tissue engineering and regenerative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Cold Atmospheric Plasma in Wound Healing: Molecular Mechanism of Action.International journal of molecular sciences · 2026Review
- Inhibition of Inflammation by an Air-Based No-Ozone Cold Plasma in TNF-α-Induced Human Keratinocytes: An In Vitro Study.Current issues in molecular biology · 2026Article
- Nonthermal Atmospheric Plasma Modulates Palatal Wound Healing in Rats: A Morphometric, Histopathologic and Immunohistochemical Analysis.Biomedicines · 2026Article
- Mechanisms of extracorporeal shock wave therapy in burn scar repair: Advances in immunoactivation-based scar remodeling research.Regenerative therapy · 2025Review
- Wound healing improvement by a multicomponent wound dressing of keratinocyte-imprinted polydimethylsiloxane substrate in a rabbit model.Scientific reports · 2025Article
- Combined treatment of melatonin and alpha-lipoic acid facilitates wound healing in rat palate: A macroscopic, histological, and immunohistochemical study.Histochemistry and cell biology · 2025Article
- Advancing chronic and acute wound healing with cold atmospheric plasma: cellular and molecular mechanisms, benefits, risks, and future directions.Frontiers in medicine · 2025Review
- Smart Dressings and Their Applications in Chronic Wound Management.Cell biochemistry and biophysics · 2024Review
- Basic research and clinical exploration of cold atmospheric plasma for skin wounds.Bioengineering & translational medicine · 2023Article
- [Effects of advanced platelet-rich fibrin on deep partial-thickness burn wounds in nude mice].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Article
- Effect of Hypertrophic Scar Fibroblast-Derived Exosomes on Keratinocytes of Normal Human Skin.International journal of molecular sciences · 2023Article
- Cold Atmospheric Plasma Jet Treatment Improves Human Keratinocyte Migration and Wound Closure Capacity without Causing Cellular Oxidative Stress.International journal of molecular sciences · 2022Article
- Article
- Applications of Plasma-Activated Liquid in the Medical Field.Biomedicines · 2021Review
- Effect of extracorporeal shock wave therapy on keratinocytes derived from human hypertrophic scars.Scientific reports · 2021Article
- Treatment of atopic dermatitis using non-thermal atmospheric plasma in an animal model.Scientific reports · 2021Article
- Polydeoxyribonucleotide-delivering therapeutic hydrogel for diabetic wound healing.Scientific reports · 2020Article
- Utility of Reactive Species Generation in Plasma Medicine for Neuronal Development.Biomedicines · 2020Review
- Effect of Combining Low Temperature Plasma, Negative Pressure Wound Therapy, and Bone Marrow Mesenchymal Stem Cells on an Acute Skin Wound Healing Mouse Model.International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow temperature plasma (LTP) was recently shown to be potentially useful for biomedical applications such as bleeding cessation, cancer treatment, and wound healing, among others. Keratinocytes are a major cell type that migrates directionally into the wound bed, and their proliferation leads to complete wound closure during the cutaneous repair/regeneration process. However, the beneficial effects of LTP on human keratinocytes have not been well studied. Therefore, we investigated migration, growth factor production, and cytokine secretion in primary human keratinocytes after LTP treatment.
methodsPrimary cultured keratinocytes were obtained from human skin biopsies. Cell viability was measured with the EZ-Cytox cell viability assay, cell migration was evaluated by an
resultsCell migration, the secretion of several cytokines, and gene and protein levels of angiogenic growth factors increased in LTP-treated human keratinocytes without associated cell toxicity. LTP treatment also significantly induced the expression of hypoxia inducible factor-1α (HIF-1α), an upstream regulator of angiogenesis. Further, the inhibition of HIF-1α expression blocked the production of angiogenic growth factors induced by LTP in human keratinocytes.
conclusionOur results suggest that LTP treatment is an effective approach to modulate wound healing-related molecules in epidermal keratinocytes and might promote angiogenesis, leading to improved wound healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.