ReviewTissue engineering and regenerative medicine2019
Current Progress in Tendon and Ligament Tissue Engineering.
Review in Tissue engineering and regenerative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
106 citing papers in PubMed, 3 syntheses or guidelines pooled it, 222 citations in OpenAlex.
- Comparing the Efficacy and Safety of Cell Transplantation for Spinal Cord Injury: A Systematic Review and Bayesian Network Meta-Analysis.Frontiers in cellular neuroscience · 2022Pooled it
- Pooled it
- A Systematic Review of Tissue Engineering Scaffold in Tendon Bone HealingFrontiers in bioengineering and biotechnology · 2021Pooled it
- PIEZO1 Is a Contextual Mechanosensor and Its Depletion in Scx-Lineage Cells Accelerates Structural and Functional Recovery.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review.Advanced healthcare materials · 2026Review
- Nanofiber based transformative approaches for tendon regenerative engineering: past, present and future.Nanomedicine (London, England) · 2026Review
- Mechanotransduction and its impact on regenerative medicine in orthopedic rehabilitation (Review).International journal of molecular medicine · 2026Review
- Review
- Photosensitive and extracellular matrix-mimicking hydrogels promote the tendon-bone healing in rotator cuff injury.Journal of materials science. Materials in medicine · 2026Article
- Biohybrid Tendons Enhance the Power-to-Weight Ratio and Modularity of Muscle-Powered Robots.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Bmscs loaded exosome hydrogel promotes the repair of rotator cuff injury in rats in vivo.Scientific reports · 2026Article
- Corrigendum to "Strong living scaffolds for load-bearing musculoskeletal tissue regeneration" [Mater. Today Bio 35 (2025) 102571].Materials today. Bio · 2026Article
- Mesenchymal stem cell-derived extracellular matrix for musculoskeletal tissue regeneration.Communications biology · 2026Review
- Effect of Human Amniotic Membrane with Aligned Electrospun Nanofiber Transplantation on Tendon Regeneration in Rats.International journal of molecular sciences · 2026Article
- Advanced engineering strategies for biomaterial scaffolds application in tendon-bone interface regeneration.Burns & trauma · 2026Review
- Advances in ultrasound-assisted drug delivery and clinical application.Ultrasonics sonochemistry · 2026Review
- Article
- Strong living scaffolds for load-bearing musculoskeletal tissue regeneration.Materials today. Bio · 2025Review
- Review
46 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Tendon and ligament injuries accounted for 30% of all musculoskeletal consultations with 4 million new incidences worldwide each year and thus imposed a significant burden to the society and the economy. Damaged tendon and ligament can severely affect the normal body movement and might lead to many complications if not treated promptly and adequately. Current conventional treatment through surgical repair and tissue graft are ineffective with a high rate of recurrence. Methods: In this review, we first discussed the anatomy, physiology and pathophysiology of tendon and ligament injuries and its current treatment. Secondly, we explored the current role of tendon and ligament tissue engineering, describing its recent advances. After that, we also described stem cell and cell secreted product approaches in tendon and ligament injuries. Lastly, we examined the role of the bioreactor and mechanical loading in in vitro maturation of engineered tendon and ligament. Results: Tissue engineering offers various alternative ways of treatment from biological tissue constructs to stem cell therapy and cell secreted products. Bioreactor with mechanical stimulation is instrumental in preparing mature engineered tendon and ligament substitutes in vitro. Conclusions: Tissue engineering showed great promise in replacing the damaged tendon and ligament. However, more study is needed to develop ideal engineered tendon and ligament.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.