ReviewCureus2019
Stauffer Syndrome: A Comprehensive Review of the Icteric Variant of the Syndrome.
Review in Cureus, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Severe Cholestatic Jaundice as the Initial Manifestation of Radiologically Occult Metastatic Prostate Cancer: An Icteric Variant of Stauffer Syndrome.European journal of case reports in internal medicine · 2026Article
- Association Between Renal Cell Cancer and Chronic Kidney Disease: An Update on a Never-Healing Wound.Biomedicines · 2025Review
- Unusual presentation of Stauffer syndrome in post Whipple patient: case report.Urology case reports · 2025Article
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- Icteric Variant of Stauffer Syndrome as a Paraneoplastic Manifestation of Type 1 Papillary Renal Cell Carcinoma.ACG case reports journal · 2023Article
- A case report: A rare case of icteric variant of Stauffer's syndrome.International journal of surgery case reports · 2023Article
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- Mild elevation of liver function tests associated with renal cell carcinoma in a multimorbid older patient - a case of Stauffer's syndrome.Central European journal of urology · 2023Article
- Hyperbilirubinemia Following Retroperitoneal Mass Resection in a Patient with Sickle Cell Anemia.Urology · 2022Article
- Renal cell carcinoma presented with a rare case of icteric Stauffer syndrome: A case report.World journal of clinical cases · 2022Article
- Severe Cholestatic Jaundice (Stauffer Syndrome) as a Rare Paraneoplastic Manifestation in Adrenocortical Carcinoma.Journal of the Endocrine Society · 2022Article
- Prostate Cancer Presenting with Pruritus and Cholestasis.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2021Article
- Predictive role of γ-glutamyltransferase in patients receiving nivolumab therapy for metastatic renal cell carcinoma.International journal of clinical oncology · 2021Article
- Stauffer syndrome, clinical implications and knowledge gaps, does size matter? Case report.BMC urology · 2020Review
- A Rare Presentation of Stauffer's Syndrome Associated with Renal Cell Carcinoma.Case reports in oncologyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stauffer syndrome is a rare paraneoplastic syndrome classically associated with renal cell carcinoma (RCC). This association gave it the historical name of nonmetastatic nephrogenic hepatic dysfunction syndrome without jaundice. It is a syndrome of unclear pathophysiology characterized by a reversible anicteric elevation of liver enzymes, alkaline phosphatase, erythrocyte sedimentation rate (ESR), thrombocytosis, prolongation of prothrombin time, and hepatosplenomegaly in the absence of direct hepatobiliary obstruction or jaundice. A rare atypical variant of this syndrome with jaundice has been recently described in the literature. Thus, it is important to consider both these variants of Stauffer syndrome in the differential diagnosis of unexplained cholestasis in the absence of hepatic metastasis. This may allow early recognition and treatment of an occult malignancy. Herein, we present a comprehensive review of the literature available on the icteric variant of the Stauffer syndrome, outlining its association with various malignancies and the diagnostic challenges it poses. The objective of this review is to help clinicians in its early diagnosis and management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.