ArticlePeerJ2019
Different distant metastasis patterns based on tumor size could be found in extensive-stage small cell lung cancer patients: a large, population-based SEER study.
Article in PeerJ, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of PD-1/PD-L1 inhibitor plus chemotherapy versus chemotherapy alone as first-line treatment for extensive-stage small cell lung cancer: A systematic review and meta-analysis.Thoracic cancer · 2020Pooled it
- Tumor-associated collagen signature in relation to metastasis in lung adenocarcinoma.Journal of thoracic disease · 2026Article
- A nomogram predicting prognosis of extensive-stage small cell lung cancer patients receiving chemoradiotherapy.Radiation oncology (London, England) · 2025Article
- A SEER prognostic nomogram analysis for extensive-stage small cell lung cancer: comparing the immune checkpoint inhibitors (ICIs) and non-ICIs eras.Journal of thoracic disease · 2025Article
- Machine Learning Models to Predict Bone Metastasis Risk in Patients With Lung Cancer.Cancer medicine · 2024Article
- Distant metastasis patterns among lung cancer subtypes and impact of primary tumor resection on survival in metastatic lung cancer using SEER database.Scientific reports · 2024Article
- Lung adenocarcinoma size as a predictor of distant metastasis: A CT scan-based measurement.Narra J · 2024Article
- Patterns of distant metastasis and survival outcomes inFrontiers in endocrinology · 2024Article
- Deep learning of bone metastasis in small cell lung cancer: A large sample-based study.Frontiers in oncology · 2023Article
- Machine Learning for the Prediction of Synchronous Organ-Specific Metastasis in Patients With Lung Cancer.Frontiers in oncology · 2022Article
- Diagnostic and prognostic nomograms for bone metastasis in small cell lung cancer.The Journal of international medical research · 2021Article
- Risk and prognostic nomograms for colorectal neuroendocrine neoplasm with liver metastasis: a population-based study.International journal of colorectal disease · 2021Article
- Association of Race, Socioeconomic Factors, and Treatment Characteristics With Overall Survival in Patients With Limited-Stage Small Cell Lung Cancer.JAMA network open · 2021Article
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Authors and funding
6 authors.
Funding
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Abstract
backgroundSmall-cell lung cancer (SCLC) is a malignant cancer with the ability to metastasize quickly. The relationship between tumor size and the distant metastasis patterns of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) has not been reported.
objectivesThe aim of this study was to determine the different distant metastasis patterns as they related to tumor size in ES-SCLC. PATIENTS AND
methodsWe used Surveillance, Epidemiology, and End Results (SEER) population-based data collected from 2010 through 2013 to identify 11058 ES-SCLC patients with definite evidence of distant metastases. Multivariate logistic regression analysis was used to demonstrate the association between tumor size and distant metastasis patterns including bone, liver, brain, and lung metastases. Age, race, sex, and N stage were also selected in the logistic regression model.
resultsSubtle differences in metastasis patterns were found among patients based on different tumor sizes. Patients with tumors 3-7 cm have a higher risk of bone metastasis compared with those that have tumors ≤3 cm (OR 1.165, 95% CI [1.055-1.287],
conclusionThe pattern of distant metastasis of ES-SCLC is related to the tumor size and the tumor size is indicative of the metastatic site. Larger tumor sizes did not correlate with a higher risk of distant metastasis, but the size is related to the pattern of distant metastasis. The study of different distant metastasis patterns based on tumor size and other clinical features (e.g., age, race, sex, and N stage) in ES-SCLC is clinically valuable.
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