Evidence map›Paper›PMID 31824650›Full record

ReviewF1000Research2019

Multifaceted circuit functions of adult-born neurons.

Cristina V Dieni, Jose Carlos Gonzalez, Linda Overstreet-Wadiche

Abstract readReview
In one paragraph

Review in F1000Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cristina V DieniDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Jose Carlos GonzalezDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Linda Overstreet-WadicheDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.ORCID 0000-0001-7367-5998

Funding

Newborn Neurons in the Adult Hippocampal NetworkR01NS064025 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OVERSTREET-WADICHE, LINDA · 2009 to 2023
$5.6M
Inhibitory Neural Circuits in Dentate FunctionR01NS105438 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI OVERSTREET-WADICHE, LINDA · 2018 to 2022
$2.1M
NINDS NIH HHS R01 NS064025NINDS NIH HHS R01 NS105438
6 · The paper itself

Abstract

The dentate gyrus continually produces new neurons throughout life. Behavioral studies in rodents and network models show that new neurons contribute to normal dentate functions, but there are many unanswered questions about how the relatively small population of new neurons alters network activity. Here we discuss experimental evidence that supports multiple cellular mechanisms by which adult-born neurons contribute to circuit function. Whereas past work focused on the unique intrinsic properties of young neurons, more recent studies also suggest that adult-born neurons alter the excitability of the mature neuronal population via unexpected circuit interactions.

Indexed as

NeurogenesisNeuronsAdultDentate GyrusHumansadult neurogenesiscircuitdentate gyrusexcitabilityglutamateinhibition

Identifiers

PMID31824650
PMCPMC6880266

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.