Evidence map›Paper›PMID 31824586›Full record

ArticleJournal of antivirals & antiretrovirals2019

The Botanical Glycoside Oleandrin Inhibits Human T-cell Leukemia Virus Type-1 Infectivity and Env-Dependent Virological Synapse Formation.

Tetiana Hutchison, Laçin Yapindi, Aditi Malu, Robert A Newman, K Jagannadha Sastry, Robert Harrod

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of antivirals & antiretrovirals, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Antiviral activity of oleandrin and a defined extract of Nerium oleander against SARS-CoV-2.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021
    Article
  3. Antiviral effects of oleandrin.Journal of the American College of Emergency Physicians open · 2021
    Article
  4. Article
  5. Antiviral Effects of Oleandrin.Journal of experimental pharmacology · 2020
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tetiana HutchisonLaboratory of Molecular Virology, Department of Biological Sciences, The Dedman College Center for Drug Discovery, Design & Delivery, Southern Methodist University, Dallas, Texas, 75275-0376, USA.
Laçin YapindiLaboratory of Molecular Virology, Department of Biological Sciences, The Dedman College Center for Drug Discovery, Design & Delivery, Southern Methodist University, Dallas, Texas, 75275-0376, USA.
Aditi MaluLaboratory of Molecular Virology, Department of Biological Sciences, The Dedman College Center for Drug Discovery, Design & Delivery, Southern Methodist University, Dallas, Texas, 75275-0376, USA.
Robert A NewmanDepartment of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, 77054, USA.
K Jagannadha SastryDepartments of Immunology and Veterinary Sciences, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, 77054, USA.
Robert HarrodLaboratory of Molecular Virology, Department of Biological Sciences, The Dedman College Center for Drug Discovery, Design & Delivery, Southern Methodist University, Dallas, Texas, 75275-0376, USA.
Southern Methodist University · USThe University of Texas MD Anderson Cancer Center · US

Funding

Coordinate Regulation of p53 and c-Myc in HTLV-1 and HPV-induced CarcinogenesisR15CA202265 · NCI · SOUTHERN METHODIST UNIVERSITY · PI HARROD, ROBERT L. · 2016 to 2016
$437k
NCI NIH HHS R15 CA202265
6 · The paper itself

Abstract

At present, there are no antiretroviral drugs that inhibit incorporation of the envelope glycoprotein into newly-synthesized virus particles. The botanical glycoside, oleandrin, derived from extracts of Nerium oleander, has previously been shown to reduce the levels of the gp120 envelope glycoprotein on human immunodeficiency virus type-1 (HIV-1) particles and inhibit HIV-1 infectivity

Indexed as

AntiviralApoptosisEnvelope glycoproteinHAARTHAM/TSPHIV-1HTLV-1Nerium oleanderOleandrin

Identifiers

PMID31824586
PMCPMC6904119
OpenAlexW2973415473

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.