Evidence map›Paper›PMID 31824511›Full record

ArticleFrontiers in immunology2019

Harnessing the Immunomodulatory Properties of Bacterial Ghosts to Boost the Anti-mycobacterial Protective Immunity.

Jieling Lim, Vanessa Hui Qi Koh, Sharol Su Lei Cho, Balamurugan Periaswamy, Dawn Poh Sum Choi, Maurizio Vacca, Paola Florez De Sessions, Pavol Kudela, Werner Lubitz, Giorgia Pastorin and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Protective Immunity againstInternational journal of molecular sciences · 2022
    Article
  8. Article
  9. Hydrochloric acid-treatedMolecular & cellular toxicology · 2022
    Article
  10. Review
  11. Review
  12. Article
  13. Bacteria-Inspired Nanomedicine.ACS applied bio materials · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jieling LimDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Vanessa Hui Qi KohDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Sharol Su Lei ChoDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Balamurugan PeriaswamyGenome Institute of Singapore, Agency for Science, Technology and Research (ASTAR), Singapore, Singapore.
Dawn Poh Sum ChoiGenome Institute of Singapore, Agency for Science, Technology and Research (ASTAR), Singapore, Singapore.
Maurizio VaccaDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Paola Florez De SessionsGenome Institute of Singapore, Agency for Science, Technology and Research (ASTAR), Singapore, Singapore.
Pavol KudelaBiotech Innovation Research Development & Consulting (BIRD-C), Vienna, Austria.
Werner LubitzBiotech Innovation Research Development & Consulting (BIRD-C), Vienna, Austria.
Giorgia PastorinDepartment of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.
Sylvie AlonsoDepartment of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
National University of Singapore · SGAgency for Science, Technology and Research · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis (TB) pathogenesis is characterized by inadequate immune cell activation and delayed T cell response in the host. Recent immunotherapeutic efforts have been directed at stimulating innate immunity and enhancing interactions between antigen presenting cells and T cells subsets to improve the protective immunity against TB. In this study, we investigated the immunostimulatory properties of bacterial ghosts (BG) as a novel approach to potentiate the host immunity against mycobacterial infection. BG are intact cytoplasm-free

Indexed as

Cell WallTuberculosis, PulmonaryTuberculosis VaccinesAnimalsCytokinesDendritic CellsEscherichia coliLipopolysaccharidesLungMiceT-LymphocytesToll-Like Receptor 4CytokinesLipopolysaccharidesTlr4 protein, mouseToll-Like Receptor 4Tuberculosis Vaccinesadjunct immune therapybacterial ghostsdrug resistancehost-directed therapytuberculosis

Identifiers

PMID31824511
PMCPMC6883722
OpenAlexW2990586931

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.