Evidence map›Paper›PMID 31824479›Full record

ArticleFrontiers in immunology2019

Complement Receptor 1 (CR1, CD35) Polymorphisms and Soluble CR1: A Proposed Anti-inflammatory Role to Quench the Fire of "Fogo Selvagem" Pemphigus Foliaceus.

Luana Caroline Oliveira, Gabriela Canalli Kretzschmar, Andressa Cristina Moraes Dos Santos, Carolina Maciel Camargo, Renato Mitsunori Nisihara, Ticiana Della Justina Farias, Andre Franke, Michael Wittig, Enno Schmidt, Hauke Busch and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Structural biology of complement receptors.Frontiers in immunology · 2023
    Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. The Neurovascular Unit Dysfunction in Alzheimer's Disease.International journal of molecular sciences · 2021
    Review
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Luana Caroline OliveiraLaboratory of Human Molecular Genetics, Department of Genetics, Federal University of Paraná, Curitiba, Brazil.
Gabriela Canalli KretzschmarLaboratory of Human Molecular Genetics, Department of Genetics, Federal University of Paraná, Curitiba, Brazil.
Andressa Cristina Moraes Dos SantosLaboratory of Human Molecular Genetics, Department of Genetics, Federal University of Paraná, Curitiba, Brazil.
Carolina Maciel CamargoLaboratory of Human Molecular Genetics, Department of Genetics, Federal University of Paraná, Curitiba, Brazil.
Renato Mitsunori NisiharaLaboratory of Molecular Immunopathology, Department of Clinical Pathology, Clinical Hospital, Federal University of Paraná, Curitiba, Brazil.
Ticiana Della Justina FariasLaboratory of Human Molecular Genetics, Department of Genetics, Federal University of Paraná, Curitiba, Brazil.
Andre FrankeInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Michael WittigInstitute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Enno SchmidtLübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Hauke BuschLübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Maria Luiza Petzl-ErlerLaboratory of Human Molecular Genetics, Department of Genetics, Federal University of Paraná, Curitiba, Brazil.
Angelica Beate Winter BoldtLaboratory of Human Molecular Genetics, Department of Genetics, Federal University of Paraná, Curitiba, Brazil.
Universidade Federal do Paraná · BRKiel University · DEUniversity of Lübeck · DEHospital de Clínicas Universidade Federal do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pemphigus foliaceus is an autoimmune disease that is sporadic around the world but endemic in Brazil, where it is known as fogo selvagem (FS). Characterized by autoantibodies against the desmosomal cadherin desmoglein 1, FS causes painful erosions, and crusts that may be widespread. The recognition of antigens, including exposed sugar moieties, activates the complement system. Complement receptor 1 (CR1, CD35), which is responsible for the Knops blood group on erythrocytes (York and McCoy antigens), is also expressed by antigen-presenting cells. This regulates the complement system by removing opsonized antigens, blocking the final steps of the complement cascade. Membrane-bound CR1 also fosters antigen presentation to B cells, whereas soluble CR1 has anti-inflammatory properties.

Indexed as

Polymorphism, GeneticAdolescentAdultAgedAged, 80 and overAllelesBiomarkersCase-Control StudiesDisease SusceptibilityFemaleGenetic LociGenetic Predisposition to DiseaseHaplotypesHumansMaleMiddle AgedBiomarkersCR1 protein, humanReceptors, Complement 3bRNA, MessengerCD35complement receptor 1CR1fogo selvagemMcCoy blood antigenpemphigus foliaceuspolymorphismYork blood antigen

Identifiers

PMID31824479
PMCPMC6883348
OpenAlexW2981381072

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.