Evidence map›Paper›PMID 31824476›Full record

ArticleFrontiers in immunology2019

Inhibition of miR-378a-3p by Inflammation Enhances IL-33 Levels: A Novel Mechanism of Alarmin Modulation in Ulcerative Colitis.

Karen Dubois-Camacho, David Diaz-Jimenez, Marjorie De la Fuente, Rodrigo Quera, Daniela Simian, Maripaz Martínez, Glauben Landskron, Mauricio Olivares-Morales, John A Cidlowski, Xiaojiang Xu and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
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  7. Effects ofNanomaterials (Basel, Switzerland) · 2024
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  17. Cytokines and microRNAs in SARS-CoV-2: What do we know?Molecular therapy. Nucleic acids · 2022
    Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Karen Dubois-CamachoInnate Immunity Laboratory, Immunology Program, Faculty of Medicine, Biomedical Sciences Institute, Universidad de Chile, Santiago, Chile.
David Diaz-JimenezInnate Immunity Laboratory, Immunology Program, Faculty of Medicine, Biomedical Sciences Institute, Universidad de Chile, Santiago, Chile.
Marjorie De la FuenteInnate Immunity Laboratory, Immunology Program, Faculty of Medicine, Biomedical Sciences Institute, Universidad de Chile, Santiago, Chile.
Rodrigo QueraInflammatory Bowel Disease Program, Gastroenterology Department, Clínica Las Condes, Santiago, Chile.
Daniela SimianResearch Sub-direction, Academic Direction, Clínica Las Condes, Santiago, Chile.
Maripaz MartínezResearch Sub-direction, Academic Direction, Clínica Las Condes, Santiago, Chile.
Glauben LandskronInnate Immunity Laboratory, Immunology Program, Faculty of Medicine, Biomedical Sciences Institute, Universidad de Chile, Santiago, Chile.
Mauricio Olivares-MoralesInnate Immunity Laboratory, Immunology Program, Faculty of Medicine, Biomedical Sciences Institute, Universidad de Chile, Santiago, Chile.
John A CidlowskiLaboratory of Signal Transduction, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institute of Health, Durham, NC, United States.
Xiaojiang XuLaboratory of Integrative Bioinformatics, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, United States.
Guangping GaoGene Therapy Center, University of Massachusetts Medical School, Worcester, MA, United States.
Jun XieGene Therapy Center, University of Massachusetts Medical School, Worcester, MA, United States.
Jonás ChnaidermanMolecular and Cellular Virology Laboratory, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
Ricardo Soto-RifoMolecular and Cellular Virology Laboratory, Virology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
María-Julieta GonzálezCell and Molecular Biology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
Andrea CalixtoCenter for Genomics and Bioinformatics, Faculty of Sciences, Universidad Mayor, Santiago, Chile.
Marcela A HermosoInnate Immunity Laboratory, Immunology Program, Faculty of Medicine, Biomedical Sciences Institute, Universidad de Chile, Santiago, Chile.
University of Chile · CLClínica Las Condes · CLNational Institute of Environmental Health Sciences · USUniversity of Massachusetts Chan Medical School · USUniversity of Valparaíso · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by mucosa damage associated with an uncontrolled inflammatory response. This immunological impairment leads to altered inflammatory mediators such as IL-33, which is shown to increase in the mucosa of active UC (aUC) patients. MicroRNAs present a distorted feature in inflamed colonic mucosa and are potential IL-33 regulating candidates in UC. Therefore, we studied the microRNA and mRNA profiles in inflamed colonic samples of UC patients, evaluating the effect of a microRNA (selected by

Indexed as

Gene Expression RegulationAdolescentAdultAgedAlarminsAnti-Inflammatory Agents, Non-SteroidalBiopsyCell LineColitis, UlcerativeFemaleHumansImmunosuppressive AgentsInterleukin-33Intestinal MucosaMaleMetabolic Networks and PathwaysAlarminsAnti-Inflammatory Agents, Non-SteroidalIL33 protein, humanImmunosuppressive AgentsInterleukin-33MicroRNAsMIRN378 microRNA, humanRNA, MessengerTumor Necrosis Factor-alphaalarminIBDIL-33microRNAmicroRNA familymiR-378a-3pPPARGC1Bulcerative colitis

Identifiers

PMID31824476
PMCPMC6879552
OpenAlexW2981216329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.