Evidence map›Paper›PMID 31824475›Full record

Trial reportFrontiers in immunology2019

Polymorphisms in the Mitochondrial Genome Are Associated With Bullous Pemphigoid in Germans.

Juliane Russlies, Anke Fähnrich, Mareike Witte, Junping Yin, Sandrine Benoit, Regine Gläser, Claudia Günter, Rüdiger Eming, Jeanette Erdmann, Damian Gola and 17 more

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 8 institutions in 3 countries.

Juliane RussliesLuebeck Institute of Experimental Dermatology, University of Luebeck, Luebeck, Germany.
Anke FähnrichLuebeck Institute of Experimental Dermatology, University of Luebeck, Luebeck, Germany.
Mareike WitteLuebeck Institute of Experimental Dermatology, University of Luebeck, Luebeck, Germany.
Junping YinResearch Center Borstel, Leibniz-Center for Medicine and Bioscience, Borstel, Germany.
Sandrine BenoitDepartment of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.
Regine GläserThe German Autoimmune Bullous Disease Genetic Study Group, Germany.
Claudia GünterThe German Autoimmune Bullous Disease Genetic Study Group, Germany.
Rüdiger EmingThe German Autoimmune Bullous Disease Genetic Study Group, Germany.
Jeanette ErdmannInstitute for Cardiogenetics, University of Luebeck, Luebeck, Germany.
Damian GolaInstitute of Medical Biometry and Statistics, University of Luebeck, Luebeck, Germany.
Yask GuptaLuebeck Institute of Experimental Dermatology, University of Luebeck, Luebeck, Germany.
Maike Marleen HoltscheDepartment of Dermatology, University of Luebeck, Luebeck, Germany.
Johannes S KernThe German Autoimmune Bullous Disease Genetic Study Group, Germany.
Inke R KönigInstitute of Medical Biometry and Statistics, University of Luebeck, Luebeck, Germany.
Dimitra KiritsiThe German Autoimmune Bullous Disease Genetic Study Group, Germany.
Wolfgang LiebInstitute of Epidemiology, Christian-Albrecht University of Kiel, Kiel, Germany.
Christian D SadikDepartment of Dermatology, University of Luebeck, Luebeck, Germany.
Miklós SárdyThe German Autoimmune Bullous Disease Genetic Study Group, Germany.
Franziska SchauerThe German Autoimmune Bullous Disease Genetic Study Group, Germany.
Nina van BeekDepartment of Dermatology, University of Luebeck, Luebeck, Germany.
Anke WeidingerThe German Autoimmune Bullous Disease Genetic Study Group, Germany.
Margitta WormThe German Autoimmune Bullous Disease Genetic Study Group, Germany.
Detlef ZillikensDepartment of Dermatology, University of Luebeck, Luebeck, Germany.
Enno SchmidtLuebeck Institute of Experimental Dermatology, University of Luebeck, Luebeck, Germany.
Hauke BuschLuebeck Institute of Experimental Dermatology, University of Luebeck, Luebeck, Germany.
Saleh M IbrahimLuebeck Institute of Experimental Dermatology, University of Luebeck, Luebeck, Germany.
Misa HiroseLuebeck Institute of Experimental Dermatology, University of Luebeck, Luebeck, Germany.
University of Lübeck · DEGerman Inflammatory Bowel Diseases Study Group · DEInstitute for Integrative and Experimental Genomics · DEUniversity of Freiburg · DEKiel University · DEPhilipps University of Marburg · DEResearch Center Borstel - Leibniz Lung Center · DEUniversitätsklinikum Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bullous pemphigoid (BP) is the most prevalent autoimmune skin blistering disease and is characterized by the generation of autoantibodies against the hemidesmosomal proteins BP180 (type XVII collagen) and BP230. Most intriguingly, BP is distinct from other autoimmune diseases because it predominantly affects elderly individuals above the age of 75 years, raising the question why autoantibodies and the clinical lesions of BP emerges mostly in this later stage of life, even in individuals harboring known putative BP-associated germline gene variants. The mitochondrial genome (mtDNA) is a potential candidate to provide additional insights into the BP etiology; however, the mtDNA has not been extensively explored to date. Therefore, we sequenced the whole mtDNA of German BP patients (

Indexed as

DNA, MitochondrialNADH DehydrogenasePemphigoid, BullousPolymorphism, Single NucleotideAgedAged, 80 and overAutoantibodiesAutoantigensCollagen Type XVIIDystoninFemaleGenome, MitochondrialHigh-Throughput Nucleotide SequencingHumansMaleNon-Fibrillar CollagensAutoantibodiesAutoantigensCollagen Type XVIIDNA, MitochondrialDST protein, humanDystoninNADH DehydrogenaseNADH dehydrogenase subunit 4Non-Fibrillar Collagensautoimmune skin diseasesbullous pemphigoidmitochondrial DNAmitochondrial functionmitochondrial haplogroupnext generation sequencingpolymorphisms

Identifiers

PMID31824475
PMCPMC6883920
OpenAlexW2971219543

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.