ArticleFrontiers in physiology2019
Altered Hemorheology in Fontan Patients in Normoxia and After Acute Hypoxic Exercise.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Cardiopulmonary exercise response at high altitude in patients with congenital heart disease: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2024Pooled it
- Iron deficiency and reduced exercise tolerance in adult Fontan patients.Frontiers in pediatrics · 2026Article
- Influence of Simulated Altitude Exposure (2500 m) on Patients with Fontan Palliation Based on Circulating Hypoxia-Associated Factors.International journal of molecular sciences · 2025Article
- Placental Sonomorphologic Appearance and Fetomaternal Outcome in Fontan Circulation.Journal of clinical medicine · 2024Article
- Decreased erythrocyte aggregation in Glenn and Fontan: univentricular circulation as a rheologic disease model.Pediatric research · 2024Article
- Influence of 24 h Simulated Altitude on Red Blood Cell Deformability and Hematological Parameters in Patients with Fontan Circulation.Metabolites · 2022Article
- Systemic ventricular function in Fontan patients at rest and after exercise at altitude.Frontiers in pediatrics · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Fontan circulation is a unique palliation procedure for several congenital heart defects. Impaired exercise capacity has previously been demonstrated in these patients and also a higher risk for cardiopulmonary mortality. Hemorheology was shown to affect cardiopulmonary capacity and in turn to be affected by regular exercise and hypoxia but none of these have been investigated in Fontan patients so far. The aim of this study was to detect general differences in hemorheology in normoxia as well as possible altered hemorheological responses to hypoxia exposure and hypoxic exercise between Fontan patients and healthy controls. METHODS AND
findings26 Fontan patients and 20 healthy controls performed an acute exercise test (AET) on a bicycle ergometer under hypoxia with ambient 15.2% oxygen saturation (sO
conclusionAcute hypoxia exposure and exercise under hypoxia might have similar impact on hemorheology in Fontan patients and controls and was clinically well tolerated. Nevertheless, exercise alters aggregation and possibly hemodynamics which requires special attention in Fontan patients.
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