Evidence map›Paper›PMID 31824321›Full record

ReviewFrontiers in pharmacology2019

Brain Metabolic Dysfunction in Early Neuropsychiatric Symptoms of Dementia.

Kok Pin Ng, Hui Jin Chiew, Pedro Rosa-Neto, Nagaendran Kandiah, Zahinoor Ismail, Serge Gauthier

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Kok Pin NgDepartment of Neurology, National Neuroscience Institute, Singapore, Singapore.
Hui Jin ChiewDepartment of Neurology, National Neuroscience Institute, Singapore, Singapore.
Pedro Rosa-NetoThe McGill University Research Centre for Studies in Aging, Montreal, QC, Canada.
Nagaendran KandiahDepartment of Neurology, National Neuroscience Institute, Singapore, Singapore.
Zahinoor IsmailDepartments of Psychiatry, Clinical Neurosciences, and Community Health Sciences, Hotchkiss Brain Institute and O'Brien Institute for Public Health, University of Calgary, Calgary, AB, Canada.
Serge GauthierThe McGill University Research Centre for Studies in Aging, Montreal, QC, Canada.
McGill University Health Centre · CANational Neuroscience Institute · SGDuke-NUS Medical School · SGUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuropsychiatric symptoms (NPS) including behavioral and psychiatric symptoms are common in the dementia stages of Alzheimer's disease (AD) and are associated with poorer outcomes in cognition, functional states, quality of life, and accelerated progression to severe dementia or death. NPS are also increasingly observed in the mild cognitive impairment stage of AD and may predict incipient dementia. As such, there is an emerging conceptual framework, which support NPS as early non-cognitive symptoms of dementia. [

Indexed as

[18F]fluorodeoxyglucose PETAlzheimer's diseasemetabolic dysfunctionmild behavioral impairmentneuropsychiatric symptoms

Identifiers

PMID31824321
PMCPMC6882863
OpenAlexW2991532750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.