Evidence map›Paper›PMID 31824299›Full record

ArticleFrontiers in aging neuroscience2019

Role of Tau Protein in Remodeling of Circadian Neuronal Circuits and Sleep.

Mercedes Arnes, Maria E Alaniz, Caline S Karam, Joshua D Cho, Gonzalo Lopez, Jonathan A Javitch, Ismael Santa-Maria

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

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  10. DYRK1a Inhibitor Mediated Rescue ofFrontiers in pharmacology · 2022
    Article
  11. Review
  12. The Reciprocal Interaction Between Sleep and Alzheimer's Disease.Advances in experimental medicine and biology · 2021
    Article
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  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mercedes ArnesTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, United States.
Maria E AlanizTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, United States.
Caline S KaramDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States.
Joshua D ChoTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, United States.
Gonzalo LopezDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Jonathan A JavitchDepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States.
Ismael Santa-MariaTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, United States.
Columbia University · USIcahn School of Medicine at Mount Sinai · US

Funding

Satellite Diagnostic and Treatment Clinic CoreP50AG008702 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DE JAGER, PHILIP L · 1989 to 2019
$46.3M
Delineating the genetic basis of amphetamine sensitivity using a Drosophila behavioral model Diversity SupplementU01DA042233 · NIDA · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI JAVITCH, JONATHAN A · 2016 to 2020
$2.2M
MicroRNA modulation of tau expression and phosphorylation in tauopathyR01NS095922 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SANTA-MARIA PEREZ, ISMAEL · 2016 to 2020
$2.0M
NIA NIH HHS P50 AG008702NIDA NIH HHS U01 DA042233NINDS NIH HHS R01 NS095922
6 · The paper itself

Abstract

Multiple neurological, physiological, and behavioral functions are synchronized by circadian clocks into daily rhythms. Neurodegenerative diseases such as Alzheimer's disease and related tauopathies are associated with a decay of circadian rhythms, disruption of sleep patterns, and impaired cognitive function but the mechanisms underlying these alterations are still unclear. Traditional approaches in neurodegeneration research have focused on understanding how pathology impinges on circadian function. Since in Alzheimer's disease and related tauopathies tau proteostasis is compromised, here we sought to understand the role of tau protein in neuronal circadian biology and related behavior. Considering molecular mechanisms underlying circadian rhythms are conserved from

Indexed as

circadian rhythmPDFsleepstructural plasticitytau

Identifiers

PMID31824299
PMCPMC6881280
OpenAlexW2989839125

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.