Evidence map›Paper›PMID 31824266›Full record

ArticleFrontiers in cellular neuroscience2019

Spinal V3 Interneurons and Left-Right Coordination in Mammalian Locomotion.

Simon M Danner, Han Zhang, Natalia A Shevtsova, Joanna Borowska-Fielding, Dylan Deska-Gauthier, Ilya A Rybak, Ying Zhang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 82 citations in OpenAlex.

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  11. Circuit Reconstruction after Traumatic Spinal Cord Injury by Cellular and Pharmacological Approaches.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  12. V2b Neurons Act via Multiple Targets to Produce in Phase Inhibition during Locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  13. Article
  14. Review
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  20. Excitatory Spinal Lhx9-Derived Interneurons Modulate Locomotor Frequency in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Simon M DannerDepartment of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA, United States.
Han ZhangDepartment of Medical Neuroscience, Brain Repair Centre, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Natalia A ShevtsovaDepartment of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA, United States.
Joanna Borowska-FieldingDepartment of Medical Neuroscience, Brain Repair Centre, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Dylan Deska-GauthierDepartment of Medical Neuroscience, Brain Repair Centre, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Ilya A RybakDepartment of Neurobiology and Anatomy, College of Medicine, Drexel University, Philadelphia, PA, United States.
Ying ZhangDepartment of Medical Neuroscience, Brain Repair Centre, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.
Dalhousie University · CADrexel University · US

Funding

Spinal cord neural circuits for left-right and flexor-extensor coordinationR01NS090919 · NINDS · DREXEL UNIVERSITY · PI GOULDING, MARTYN D, KIEHN, OLE · 2014 to 2018
$3.1M
Neural mechanisms of locomotion evoked by epidural stimulation of the spinal cordR01NS100928 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI PRILUTSKY, BORIS I · 2017 to 2021
$2.7M
CRCNS: Rhythm generation in rodent spinal cord R01NS095366 · NINDS · DREXEL UNIVERSITY · PI DOUGHERTY, KIMBERLY J · 2015 to 2019
$1.7M
6 · The paper itself

Abstract

Commissural interneurons (CINs) mediate interactions between rhythm-generating locomotor circuits located on each side of the spinal cord and are necessary for left-right limb coordination during locomotion. While glutamatergic V3 CINs have been implicated in left-right coordination, their functional connectivity remains elusive. Here, we addressed this issue by combining experimental and modeling approaches. We employed Sim1

Indexed as

central pattern generatorcommissural neuronscomputational modelinglocomotionoptogenetic stimulationspinal cordV3

Identifiers

PMID31824266
PMCPMC6879559
OpenAlexW2991486723

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.