Evidence map›Paper›PMID 31824254›Full record

ArticleFrontiers in neuroscience2019

Association Between Social Cognition Changes and Resting State Functional Connectivity in Frontotemporal Dementia, Alzheimer's Disease, Parkinson's Disease, and Healthy Controls.

Namita Multani, Foad Taghdiri, Cassandra J Anor, Brenda Varriano, Karen Misquitta, David F Tang-Wai, Ron Keren, Susan Fox, Anthony E Lang, Anne Catherine Vijverman and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Facial Emotion Recognition Ability May Improve in Alzheimer Disease: A Pilot Study.Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology · 2026
    Trial
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Social Cognition in Parkinson's Disease: A Case-Control Study.Movement disorders clinical practice · 2023
    Article
  16. Social concepts and the cerebellum: behavioural and functional connectivity signatures in cerebellar ataxic patients.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Article
  17. Article
  18. Examining empathy deficits across familial forms of frontotemporal dementia within the GENFI cohort.Cortex; a journal devoted to the study of the nervous system and behavior · 2022
    Article
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Namita MultaniTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Foad TaghdiriTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Cassandra J AnorTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Brenda VarrianoTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Karen MisquittaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
David F Tang-WaiMemory Clinic, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Ron KerenMemory Clinic, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Susan FoxThe Edmond J. Safra Program for Parkinson Disease, Movement Disorder Clinic, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Anthony E LangThe Edmond J. Safra Program for Parkinson Disease, Movement Disorder Clinic, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Anne Catherine VijvermanThe Edmond J. Safra Program for Parkinson Disease, Movement Disorder Clinic, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Connie MarrasThe Edmond J. Safra Program for Parkinson Disease, Movement Disorder Clinic, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.
Maria Carmela TartagliaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the relationship between alterations in resting state functional connectivity and social cognition dysfunction among patients with frontotemporal dementia (FTD), Alzheimer's disease (AD), Parkinson's disease (PD), and healthy controls (HC).

methodsFifty-seven participants (FTD = 10, AD = 18, PD = 19, and HC = 10) underwent structural and functional imaging and completed the Awareness of Social Inference Test-Emotion Evaluation Test (TASIT-EET), Behavioral Inhibition System/Behavioral Activation System (BIS/BAS) scale, Revised Self-Monitoring Scale (RSMS), Interpersonal Reactivity Index (IRI), and Social Norms Questionnaire (SNQ). A multi-variate pattern analysis (MVPA) was carried out to determine activation differences between the groups. The clusters from the MVPA were used as seeds for the ROI-to-voxel analysis. Relationship between social cognition deficits and uncinate integrity was also investigated.

resultsBOLD signal activation differed among the four groups of AD, PD, FTD, and HC in the left inferior temporal gyrus-anterior division [L-ITG (ant)], right central opercular cortex (R-COp), right supramarginal gyrus, posterior division (R-SMG, post), right angular gyrus (R-AG), and R-ITG. The BOLD co-activation of the L-ITG (ant) with bilateral frontal pole (FP) and paracingulate gyrus was positively associated with IRI-perspective taking (PT) (

conclusionPatients with neurodegenerative diseases showed alterations in connectivity in brain regions important for social cognition compared with HCs. Functional connectivity correlated with performance on social cognition tasks and alterations could be responsible for some of the social cognition deficits observed in all neurodegenerative diseases.

Indexed as

functional connectivityneurodegenerationneuroimage analysisresting-state fMRIsocial cognition

Identifiers

PMID31824254
PMCPMC6883726

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.