Evidence map›Paper›PMID 31824158›Full record

ArticleInternational journal of nanomedicine2019

The Clinical Implication of Vitamin D Nanomedicine for Peritoneal Dialysis-Related Peritoneal Damage.

Yi-Che Lee, Chih-Ting Huang, Fong-Yu Cheng, Shih-Yuan Hung, Tsun-Mei Lin, Yen-Chang Tsai, Chih-I Chen, Hao-Kuang Wang, Chi-Wei Lin, Hung-Hsiang Liou and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Yi-Che LeeDivision of Nephrology, Department of Internal Medicine, E-DA Dachang Hospital/ I-Shou University, Kaohsiung, Taiwan.ORCID 0000-0003-4931-0248
Chih-Ting HuangInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Fong-Yu ChengDepartment of Chemistry, Chinese Culture University, Taipei, Taiwan.ORCID 0000-0002-7826-0676
Shih-Yuan HungDivision of Nephrology, Department of Internal Medicine, E-DA Hospital/ I-Shou University, Kaohsiung, Taiwan.
Tsun-Mei LinDepartment of Laboratory Medicine.
Yen-Chang TsaiInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chih-I ChenDivision of Colorectal Surgery, Department of Surgery.ORCID 0000-0002-5311-6889
Hao-Kuang WangDepartment of Neurosurgery.ORCID 0000-0002-1928-7502
Chi-Wei LinDepartment of Medical Education, E-DA Hospital/ I-Shou University, Kaohsiung, Taiwan.
Hung-Hsiang LiouDivision of Nephrology, Department of Medicine, Hsin-Jen Hospital, New Taipei City, Taiwan.
Min-Yu ChangDivision of Nephrology, Department of Internal Medicine, E-DA Hospital/ I-Shou University, Kaohsiung, Taiwan.ORCID 0000-0003-3493-8892
Hsi-Hao WangDivision of Nephrology, Department of Internal Medicine, E-DA Hospital/ I-Shou University, Kaohsiung, Taiwan.
Yuan-Yow ChiouInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID 0000-0002-5279-0660
I-Shou University · TWNational Cheng Kung University · TWChinese Culture University · TWColorectal Surgical Associates · USJen-Ai Hospital · TWNational Cheng Kung University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeVitamin D is a novel potential therapeutic agent for peritoneal dialysis (PD)-related peritoneal fibrosis, but it can induce hypercalcemia and vascular calcification, which limits its applicability. In this study, we create nanotechnology-based drug delivery systems to investigate its therapeutics and side effects. MATERIALS AND

methods1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N- [amino-(polyethylene glycol)2000] (DSPE-PEG) and L-α-phosphatidylcholine (PC), which packages with 1α,25(OH)

resultsVitamin D nanoliposomes were taken up by the mesothelial cells over time without cell toxicity and it also provided the same therapeutic effect in vitro. In vivo study, fluorescent imaging showed vitamin D nanoliposomes allow specific peritoneum target effect and also ameliorate vitamin D side effect.

conclusionNanoliposomes vitamin D delivery systems for the prevention of PD-related peritoneal damage may be a potential clinical strategy in the future.

Indexed as

NanomedicineAnimalsAntibodiesCell DeathCells, CulturedCell SurvivalDrug LiberationEpithelial-Mesenchymal TransitionHumansKineticsLiposomesMiceNanoparticlesPeritoneal DialysisPeritoneumPhosphatidylethanolaminesAntibodiesLiposomesPhosphatidylethanolaminespolyethylene glycol 2000polyethylene glycol-distearoylphosphatidylethanolaminePolyethylene GlycolsTransforming Growth Factor beta1Vitamin Dfibrosisnanoliposomeperitoneal dialysisvitamin D

Identifiers

PMID31824158
PMCPMC6901052
OpenAlexW2992093453

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.