ArticleMolecular cancer2019
N6-methyladenosine induced miR-143-3p promotes the brain metastasis of lung cancer via regulation of VASH1.
Article in Molecular cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 152 papers.
What it found
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Who cites it
152 citing papers in PubMed, 219 citations in OpenAlex.
- mJournal of translational medicine · 2025Article
- MicroRNA chemical modifications in post-transcriptional gene silencing and human diseases.Molecular therapy. Nucleic acids · 2025Review
- METTL3-mediated mAnnals of medicine · 2025Article
- G-protein coupled receptor 183 (GPR183) inhibits visceral metastasis of non-small cell lung cancer.Clinical & experimental metastasis · 2025Article
- miR-143-3p/TET1 Axis Regulates GPC1 Through DNA Methylation and Impairs the Malignant Biological Behaviour of HCC via the Hippo Signalling Pathway.Journal of cellular and molecular medicine · 2025Article
- A novel disulfidptosis-related prognostic gene signature and experimental validation identifyCancer biomarkers : section A of Disease markers · 2025Article
- Dynamic RNA methylation modifications and their regulatory role in mammalian development and diseases.Science China. Life sciences · 2024Review
- The landscape of epigenetic regulation and therapeutic application of NGenes & diseases · 2024Review
- Biological functions and potential mechanisms of miR‑143‑3p in cancers (Review).Oncology reports · 2024Review
- The role of m6A in angiogenesis and vascular diseases.iScience · 2024Review
- Overview of the interplay between m6A methylation modification and non-coding RNA and their impact on tumor cells.Translational cancer research · 2024Review
- METTL3-mediated pre-miR-665/DLX3 mExperimental & molecular medicine · 2024Article
- Association between methyltransferase-like 3 and non-small cell lung cancer: pathogenesis, therapeutic resistance, and clinical applications.Translational lung cancer research · 2024Review
- Stable Dual miR-143 and miR-506 Upregulation Inhibits Proliferation and Cell Cycle Progression.International journal of molecular sciences · 2024Article
- Single-cell RNA sequencing reveals epithelial cells driving brain metastasis in lung adenocarcinoma.iScience · 2024Article
- Non-coding RNA-Mediated N6-Methyladenosine (mNon-coding RNA research · 2024Review
- METTL14 drives growth and metastasis of non-small cell lung cancer by regulating pri-miR-93-5p maturation and TXNIP expression.Genes & genomics · 2024Article
- Regulatory effect of N6-methyladenosine on tumor angiogenesis.Frontiers in immunology · 2024Review
- N6-Methyladenosine in Cell-Fate Determination of BMSCs: From Mechanism to Applications.Research (Washington, D.C.) · 2024Article
- RNA mGenes & diseases · 2024Article
92 more citing papers are in PubMed but not listed here.
Corrections and comments
- Retraction · 2023-08-12Duplication of/in Image · Error in Image · Investigation by Third Party · Objections by Third Party · Unreliable Data · · see also: https://pubpeer.com/publications/82BBA35F7AC41257D3A2B52054F28F
- Retracted
Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBrain metastasis (BM) is one of the principal causes of mortality for lung cancer patients. While the molecular events that govern BM of lung cancer remain frustrating cloudy.
methodsThe miRNA expression profiles are checked in the paired human BM and primary lung cancer tissues. The effect of miR-143-3p on BM of lung cancer cells and its related mechanisms are investigated.
resultsmiR-143-3p is upregulated in the paired BM tissues as compared with that in primary cancer tissues. It can increase the invasion capability of in vitro blood brain barrier (BBB) model and angiogenesis of lung cancer by targeting the three binding sites of 3'UTR of vasohibin-1 (VASH1) to inhibit its expression. Mechanistically, VASH1 can increase the ubiquitylation of VEGFA to trigger the proteasome mediated degradation, further, it can endow the tubulin depolymerization through detyrosination to increase the cell motility. m
conclusionsOur work implicates a causal role of the miR-143-3p/VASH1 axis in BM of lung cancers and suggests their critical roles in lung cancer pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.