Evidence map›Paper›PMID 31823686›Full record

ReviewTranscription2020

The role of enhancer RNAs in epigenetic regulation of gene expression.

Homa Rahnamoun, Paola Orozco, Shannon M Lauberth

Abstract readReview
In one paragraph

Review in Transcription, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Interaction Between Enhancers and Promoters in Chicken Genome.International journal of molecular sciences · 2025
    Article
  2. Article
  3. Article
  4. Revisiting Epigenetics Fundamentals and Its Biomedical Implications.International journal of molecular sciences · 2024
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Homa RahnamounSection of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-0555-2328
Paola OrozcoSection of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.
Shannon M LauberthSection of Molecular Biology, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-4131-8536

Funding

GENETIC MECHANISMS AND REGULATIONT32GM007240 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMPTON, RANDOLPH Y. · 1985 to 2019
$23.8M
The Roles of Enhancer RNAs in the Regulation of Gene ExpressionR35GM128900 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LAUBERTH, SHANNON MARIE · 2018 to 2022
$2.0M
NIGMS NIH HHS R35 GM128900NIGMS NIH HHS T32 GM007240
6 · The paper itself

Abstract

Since the discovery that enhancers can support transcription, the roles of enhancer RNAs have remained largely elusive. We identified that enhancer RNAs interact with and augment bromodomain engagement with acetylated chromatin. Here, we discuss our recent findings and the potential mechanisms underlying the regulation and functions of enhancer RNA-bromodomain associations.

Indexed as

AnimalsEnhancer Elements, GeneticEpigenesis, GeneticGene Expression RegulationHumansRNARNABRD4bromodomainchromatinEnhancereRNAgene regulationhistone modificationtranscription

Identifiers

PMID31823686
PMCPMC7053929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.