ReviewAmerican journal of physiology. Regulatory, integrative and comparative physiology2020
Neural control of cardiovascular function in black adults: implications for racial differences in autonomic regulation.
Review in American journal of physiology. Regulatory, integrative and comparative physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Aerobic Cycling Exercise Training Does Not Improve Impaired Vagal Reactivation in Patients with Chronic Kidney Disease.Medicine and science in sports and exercise · 2025Trial
- Addressing Hypertension Treatment Disparities Via Renal Denervation.Current hypertension reports · 2026Review
- Effects of a single bout of low-intensity isometric or moderate-intensity aerobic exercise on postexercise hypotension in adults of African and south-Asian descent: a randomized controlled crossover trial.Frontiers in rehabilitation sciences · 2026Article
- Menopause and its effects on autonomic regulation of blood pressure: Insights and perspectives.Autonomic neuroscience : basic & clinical · 2025Review
- Maintained sympathetic reactivity but blunted pressor response to static handgrip exercise in heart failure with preserved ejection fraction.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Cardiac autonomic function in young, healthy adults: Influence of race and sex.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Article
- Circadian Blood Pressure as an Indicator for Cardiovascular Complications : CBP as an Indicator for Cardiovascular Complications.Galen medical journal · 2025Review
- Melanometry for objective evaluation of skin pigmentation in pulse oximetry studies.Communications medicine · 2024Review
- Sympathetic transduction at rest and during cold pressor test in young healthy non-Hispanic Black and White women.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- A review of the historical use of sex as a biological variable in theAmerican journal of physiology. Heart and circulatory physiology · 2023Review
- Racial Differences in Blood Pressure and Autonomic Recovery Following Acute Supramaximal Exercise in Women.International journal of environmental research and public health · 2023Article
- The exercise pressor reflex: An update.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Review
- Review
- Differential influences of dietary sodium on blood pressure regulation based on race and sex.Autonomic neuroscience : basic & clinical · 2021Review
- Factors contributing to racial differences in neurogenic orthostatic hypotension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Internalized Shame and Social Stress-Induced Blood Pressure Patterns among Young Black Women.Ethnicity & disease · 2021Article
- Examining "race" in physiology.American journal of physiology. Heart and circulatory physiology · 2020Article
- Assessment of baroreceptor reflex sensitivity in young obese Saudi males at rest and in response to physiological challenges.Physiological reports · 2020Article
- Racial and ethnic disparities in cardiometabolic disease and COVID-19 outcomes in White, Black/African American, and Latinx populations: Physiological underpinnings.Progress in cardiovascular diseasesReview
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Black adults are at increased risk for developing hypertension and cardiovascular and chronic kidney disease and have greater associated morbidity/mortality than white adults who are otherwise demographically similar. Despite the key role of the autonomic nervous system in the regulation of cardiovascular function, the mechanistic contributions of sympathetic nerves to racial differences in cardiovascular dysfunction and disease remain poorly understood. In this review, we present an update and synthesis of current understanding regarding the roles of autonomic neural mechanisms in normal and pathophysiological cardiovascular control in black and white adults. At rest, many hemodynamic and autonomic variables, including blood pressure, cardiac output, and sympathetic nerve activity, are similar in healthy black and white adults. However, resting sympathetic vascular transduction and carotid baroreflex responses are altered in ways that tend to promote increased vasoconstriction and higher blood pressure, even in healthy, normotensive black adults. Acute sympathoexcitatory maneuvers, including exercise and cold pressor test, often result in augmented sympathetic and hemodynamic responses in healthy black adults. Clinically, although mechanistic evidence is scarce in this area, existing data support the idea that excessive sympathetic activation and/or transduction into peripheral vasoconstriction contribute importantly to the pathophysiology of hypertension and chronic kidney disease in black compared with white adults. Important areas for future work include more detailed study of sympathetic and hemodynamic reactivity to exercise and other stressors in male and female black adults and, particularly, sympathetic control of renal function, an important area of clinical concern in black patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.