ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2020
Low-load resistance training to task failure with and without blood flow restriction: muscular functional and structural adaptations.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effectiveness of Blood Flow Restriction Training in Neurological Rehabilitation: A Systematic Review and Meta-analysis.Sports medicine - open · 2026Pooled it
- Potential Moderators of the Effects of Blood Flow Restriction Training on Muscle Strength and Hypertrophy: A Meta-analysis Based on a Comparison with High-Load Resistance Training.Sports medicine - open · 2024Pooled it
- Submaximal low-load resistance exercise with blood flow restriction produces similar results to low-load exercise to failure for muscle size and strength, but not endurance.European journal of applied physiology · 2026Trial
- Remote coaching with blood flow restriction training: impact on strength, body composition, metabolism, and walking energetics in overweight adults.European journal of applied physiology · 2026Article
- Blood Flow Restriction Training in Hemodialysis Patients: Clinical Benefits, Challenges, and Future Perspectives.Hemodialysis international. International Symposium on Home Hemodialysis · 2026Review
- Rethinking task failure in resistance training research: a framework for submaximal exercise prescription.European journal of applied physiology · 2026Review
- The Effect of Blood Flow Restriction Training on Rock Climbing Performance, Forearm Blood Oxygenation and Cardiovascular Responses.European journal of sport science · 2026Article
- Low-Load Blood Flow Restriction Training Enhances Brachial Blood Flow During Exercise but not Reactive Hyperemia in Experienced Climbers.Scandinavian journal of medicine & science in sports · 2026Article
- Does exercising bilaterally require measuring bilaterally? Bilateral versus unilateral tourniquet cuff inflation during measurement of arterial occlusion pressure: considerations for blood flow restriction exercise.Frontiers in physiology · 2026Article
- Review
- Impact of exercise with blood flow restriction on muscle hypertrophy and performance outcomes in men and women.PloS one · 2025Article
- Integrative effects of resistance training and endurance training on mitochondrial remodeling in skeletal muscle.European journal of applied physiology · 2024Review
- The Discrepancy Between External and Internal Load/Intensity during Blood Flow Restriction Exercise: Understanding Blood Flow Restriction Pressure as Modulating Factor.Sports medicine - open · 2024Article
- Impact of low-load resistance exercise with and without blood flow restriction on muscle strength, endurance, and oxidative capacity: A pilot study.Physiological reports · 2024Article
- Distinct adaptations of muscle endurance but not strength or hypertrophy to low-load resistance training with and without blood flow restriction.Experimental physiology · 2024Article
- Low-load resistance exercise with and without blood flow restriction: Which is more effective for increasing local muscle endurance and why?Experimental physiology · 2024Article
- Effects of 4-Week Low-Load Resistance Training with Blood Flow Restriction on Muscle Strength and Left Ventricular Function in Young Swimmers: A Pilot Randomized Trial.Journal of human kinetics · 2023Article
- Exercise-induced skeletal muscle angiogenesis: impact of age, sex, angiocrines and cellular mediators.European journal of applied physiology · 2023Review
- Fiber-Type-Specific Hypertrophy with the Use of Low-Load Blood Flow Restriction Resistance Training: A Systematic Review.Journal of functional morphology and kinesiology · 2023Review
- Beneath the cuff: Often overlooked and under-reported blood flow restriction device features and their potential impact on practice-A review of the current state of the research.Frontiers in physiology · 2023Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The application of blood flow restriction (BFR) during resistance exercise is increasingly recognized for its ability to improve rehabilitation and for its effectiveness in increasing muscle hypertrophy and strength among healthy populations. However, direct comparison of the skeletal muscle adaptations to low-load resistance exercise (LL-RE) and low-load BFR resistance exercise (LL-BFR) performed to task failure is lacking. Using a within-subject design, we examined whole muscle group and skeletal muscle adaptations to 6 wk of LL-RE and LL-BFR training to repetition failure. Muscle strength and size outcomes were similar for both types of training, despite ~33% lower total exercise volume (load × repetition) with LL-BFR than LL-RE (28,544 ± 1,771 vs. 18,949 ± 1,541 kg,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.