ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2021
Pretest models for predicting abnormal stress single-photon emission computed tomography myocardial perfusion imaging.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The value of contrast-enhanced energy-spectrum mammography combined with clinical indicators in detecting breast cancer in Breast Imaging Reporting and Data System (BI-RADS) 4 lesions.Quantitative imaging in medicine and surgery · 2024Article
- Cardiovascular risk factors and development of nomograms in an Italian cohort of patients with suspected coronary artery disease undergoing SPECT or PET stress myocardial perfusion imaging.Frontiers in nuclear medicine · 2024Article
- Combined evaluation of CAC score and myocardial perfusion imaging in patients at risk of cardiovascular disease: where are we and what do the data say.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Review
- In 2023 PET myocardial perfusion imaging is preferred to invasive coronary angiography for the initial work-up of a symptomatic patient with a high coronary artery calcium score.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Machine learning to predict hemodynamically significant CAD based on traditional risk factors, coronary artery calcium and epicardial fat volume.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Age-Specific Cardiovascular Risk Factors for Major Adverse Cardiac Events in Patients Undergoing Myocardial Perfusion Imaging.Journal of cardiovascular development and disease · 2023Article
- External validation and update of the J-ACCESS model in an Italian cohort of patients undergoing stress myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- A novel cardiovascular risk assessment tool for the prediction of myocardial ischemia on imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Development and validation of ischemia risk scores.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Prognostic value of heart rate reserve in patients with suspected coronary artery disease undergoing stress myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Assessment of the routine reporting of very low-dose exercise-first myocardial perfusion SPECT from a large-scale real-world cohort and correlation with the subsequent reporting of coronary stenosis at angiography.European journal of nuclear medicine and molecular imaging · 2022Article
- Diagnostic value of clinical risk scores for predicting normal stress myocardial perfusion imaging in subjects without coronary artery calcium.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Stress myocardial perfusion imaging: Can we tell the results without doing the test?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Nuclear cardiac imaging between implementation and globalization: The key role of integration.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- A Comparison among Different Machine Learning Pretest Approaches to Predict Stress-Induced Ischemia at PET/CT Myocardial Perfusion Imaging.Computational and mathematical methods in medicine · 2021Article
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Authors and funding
13 authors.
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Abstract
backgroundThe frequency of abnormal stress SPECT myocardial perfusion imaging (MPS) decreased over the past decades despite an increase in the prevalence of cardiovascular risk factors. These findings strengthen the need to develop more effective strategies for appropriately referring patients with suspected coronary artery disease (CAD) to cardiac imaging. The aim of this study was to develop pretest assessment models for predicting abnormal stress MPS.
methodsWe included 5,601 consecutive patients with suspected CAD, who underwent stress MPS at our academic center. Two different models were considered: a basic model including age, gender, and anginal symptoms; and a clinical model including also diabetes, hypertension, hypercholesterolemia, smoking, and family history of CAD.
resultsIn patients with abnormal MPS, the basic model classified more than 75% of patients as intermediate risk, whereas only 23% were incorrectly classified as low risk. In patients with normal MPS, 45% were correctly classified as low risk and none as high risk. Basic and clinical models had a limited discriminating capacity (area under the receiver operating characteristic curve 0.644 for basic model and 0.647 for clinical model) between individuals with and without abnormal stress MPS. The decision curve analysis demonstrates a high net benefit across a range of threshold probabilities from ~ 15% to ~30% for both models.
conclusionsA pretest risk stratification based on traditional cardiovascular risk factors has a limited value for predicting an abnormal stress MPS in patients with suspected CAD. However, selecting a proper threshold probability enhances the appropriateness of referral to stress MPS.
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