Evidence map›Paper›PMID 31823277›Full record

ArticleMagma (New York, N.Y.)2020

Stability evaluation of Gd chelates for macromolecular MRI contrast agents.

Masayuki Yokoyama, Kouichi Shiraishi

Abstract read
PubMed Publisher
In one paragraph

Article in Magma (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Masayuki YokoyamaDivision of Medical Engineering, Research Center for Medical Sciences, The Jikei University School of Medicine, 163-1, Kashiwashita, Kashiwa-shi, Chiba, 277-8567, Japan. masajun2093ryo@jikei.ac.jp.ORCID http://orcid.org/0000-0001-6053-1856
Kouichi ShiraishiDivision of Medical Engineering, Research Center for Medical Sciences, The Jikei University School of Medicine, 163-1, Kashiwashita, Kashiwa-shi, Chiba, 277-8567, Japan.

Funding

Ministry of Education, Science, Sports and Culture, Grant-in-Aid for Scientific Research (B) 26282139
6 · The paper itself

Abstract

objectiveWe try to establish designs for the macromolecular agents possessing high Gd MATERIALS AND

methodsWe prepared three types of Gd-based macromolecular MRI contrast agents from a synthetic polymer (poly(glutamic acid) homopolymer or poly(ethylene glycol)-b-poly(lysine) block copolymer) and a chelating moiety (DO3A or DOTA) having two strategic designs for high chelate stability. Then, we examine the in vitro Gd

resultsThe prepared macromolecular agents exhibited the same or higher Gd DISCUSSION: Our macromolecular design was considered to work well for high Gd

Indexed as

SolubilityChelating AgentsContrast MediaGadoliniumHeterocyclic Compounds, 1-RingMacromolecular SubstancesMagnetic Resonance ImagingMagnetic Resonance SpectroscopyPolyethylene GlycolsPolyglutamic AcidPolylysineRisk FactorsWater1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acidChelating AgentsContrast MediaGadoliniumHeterocyclic Compounds, 1-RingMacromolecular SubstancesPolyethylene GlycolsPolyglutamic AcidPolylysineWaterChelating stabilityContrast agentGd-chelateMacromolecular contrast agentPolymeric micelle

Identifiers

PMID31823277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.