ArticleEnvironmental science and pollution research international2020
Ameliorative effect of boric acid against formaldehyde-induced oxidative stress in A549 cell lines.
Article in Environmental science and pollution research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 16 citations in OpenAlex.
- Boric acid-functionalized bentonite nanostructures attenuated paraquat-induced pulmonary injuries in rats.Scientific reports · 2025Article
- Caffeic acid derivative WSY6 protects melanocytes from oxidative stress by reducing ROS production and MAPK activation.Heliyon · 2024Article
- Article
- Metal toxicity and natural antidotes: prevention is better than cure.Environmental science and pollution research international · 2020Review
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2 authors at 1 institution in 1 country.
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Abstract
Formaldehyde (HCHO) is a reactive agent and the most essential common carcinogenic environmental pollutant. The present study investigated the protective and ameliorative effects of boric acid (BA) against formaldehyde-induced oxidative stress in A549 cell lines. The first group served as a control, the second group was treated with only 100 μM formaldehyde, and the third, fourth, and fifth groups were treated with 2.5, 5, and 10 mM BA, respectively. The sixth, seventh, and eighth groups were treated with 2.5, 5, and 10 mM BA plus 100 μM formaldehyde, respectively. In A549 cell lines, formaldehyde treatment significantly decreased cell viability, glutathione level, and enzyme activities of superoxide dismutase and catalase; however, malondialdehyde levels of the cell lysate were found to increase compared with the control group. In addition, formaldehyde treatment did not significantly alter nitric oxide levels. Meanwhile, mRNA expression levels of Tnf-α, NFĸB, and caspase-3 significantly increased but the Bcl-XL level did not show significant alteration by formaldehyde treatment. In contrast, the BA treatment reversed the formaldehyde-induced alteration in A549 cell lines. Consequently, BA exhibited a protective effect in A549 cell line against formaldehyde-induced lipid peroxidation. Furthermore, it ameliorated the antioxidant status and mRNA expression levels of proinflammatory cytokines.
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