Evidence map›Paper›PMID 31823234›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2020

Impact of left atrial appendage occlusion on left atrial function-The LAFIT Watchman study.

Ghulam Murtaza, Venkat Vuddanda, Krishna Akella, Domenico G Della Rocca, Sharan Sharma, Ling Li, Shelby Kutty, Mohit Turagam, Saibal Kar, David Holmes and 1 more

Abstract read
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In one paragraph

Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  10. Surgical clip closure of the left atrial appendage.Journal of cardiovascular electrophysiology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Ghulam MurtazaThe Kansas City Heart Rhythm Institute & Research Foundation, 5100 W 110th St Second Floor, Overland Park, KS, 66211, USA.
Venkat VuddandaHarvard Medical School, 25 Shattuck St, Boston, MA, 02115, USA.
Krishna AkellaThe Kansas City Heart Rhythm Institute & Research Foundation, 5100 W 110th St Second Floor, Overland Park, KS, 66211, USA.
Domenico G Della RoccaTexas Cardiac Arrhythmia Institute, St. David's Medical Center, 3000 N Interstate Hwy 35, Austin, TX, 78705, USA.
Sharan SharmaThe Kansas City Heart Rhythm Institute & Research Foundation, 5100 W 110th St Second Floor, Overland Park, KS, 66211, USA.
Ling LiDivision of Pediatric Cardiology, Johns Hopkins Medical Center, 600 N Wolfe St, Baltimore, MD, 21205, USA.
Shelby KuttyDivision of Pediatric Cardiology, Johns Hopkins Medical Center, 600 N Wolfe St, Baltimore, MD, 21205, USA.
Mohit TuragamMt. Sinai Hospital, 1468 Madison Ave, New York, NY, 10029, USA.
Saibal Kar, Los Angeles, USA.
David HolmesMayo Clinic, Rochester, MN, USA.
Dhanunjaya LakkireddyThe Kansas City Heart Rhythm Institute & Research Foundation, 5100 W 110th St Second Floor, Overland Park, KS, 66211, USA. dlakkireddy@gmail.com.
Heart Rhythm Society · USJohns Hopkins University · USLemuel Shattuck Hospital · USMayo Clinic in Arizona · USSinai Hospital · USTexas Cardiac Arrhythmia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeft atrial (LA) strain and strain rate (SR) analysis by two-dimensional speckle tracking echocardiography is a novel way of LA function assessment. From prior study, we know that LA appendage closure with LARIAT appears to improve LA function.

objectiveThe purpose of this study was to assess the impact of LAA closure via Watchman device on LA function via strain and volumetric analyses using two-dimensional speckle tracking echocardiography (2D-STE).

methodsTwenty-five patients who underwent Watchman device implantation (WDI) were included. LA function parameters (volumetric, strain indices) were calculated from apical four chamber views with the reference point set at QRS using 2D-STE before and after WDI. LA expansion index, strain and strain rate during ventricular systole represent LA reservoir function. Passive emptying fraction, strain and strain rate during early ventricular diastole represent LA conduit function.

resultsMean age was 76 ± 6.9 years with 60% males. There was significant improvement in conduit function (LA passive emptying fraction; post 28.6 (21.9-35.9) vs pre 21.0 (13.8-34.7), p = 0.032), reservoir function (LA expansion index; post 75.3 (52.3-98.0) vs pre 58.1 (37.8-85.2), p = 0.026), and booster function (LA active emptying fraction; post 13.3 (9.7-29.9) vs pre 12.6 (8.8-25.5), p = 0.04) by volumetric indices. No significant improvement was noted with strain indices in conduit function (SRe; post - 0.56 (0.43-0.93) vs pre - 0.58 (0.46-0.87); p = 0.518) and reservoir function (SRs; post + 0.58 (0.28-0.40) vs pre + 0.52 (0.35-0.86); p = 0.851).

conclusionsWDI resulted in discrepancy of volumetric and strain indices in LA function assessment.

Indexed as

Atrial AppendageCardiac Surgical ProceduresAtrial Function, LeftEchocardiographyFemaleHeart AtriaHumansInfant, NewbornMaleLeft atrial appendageSpeckle tracking echocardiographyStrain analysisWatchman device

Identifiers

PMID31823234
OpenAlexW2995906876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.