Evidence map›Paper›PMID 31823227›Full record

ReviewNeurotoxicity research2020

NF-κB-Mediated Neuroinflammation in Parkinson's Disease and Potential Therapeutic Effect of Polyphenols.

Saumitra Sen Singh, Sachchida Nand Rai, Hareram Birla, Walia Zahra, Aaina Singh Rathore, Surya Pratap Singh

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurotoxicity research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed, 3 pooled it
8.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

128 citing papers in PubMed, 3 syntheses or guidelines pooled it, 209 citations in OpenAlex.

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  18. Aesculus hippocastanum Extract Exerts Neuroprotective Effects in an MPPJournal of cellular and molecular medicine · 2026
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68 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Saumitra Sen SinghDepartment of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India.
Sachchida Nand RaiDepartment of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India.
Hareram BirlaDepartment of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India.
Walia ZahraDepartment of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India.
Aaina Singh RathoreDepartment of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India.
Surya Pratap SinghDepartment of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, 221005, India. suryasinghbhu16@gmail.com.
Banaras Hindu University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Different animal and human studies from last two decades in the case of Parkinson's disease (PD) have concentrated on oxidative stress due to increased inflammation and cytokine-dependent neurotoxicity leading to induction of dopaminergic (DA) degeneration pathway in the nigrostriatal region. Chronic inflammation, the principle hallmark of PD, forms the basis of neurodegeneration. Aging in association with activation of glia due to neuronal injury, perhaps because of immune alterations and genetic predispositions, leads to deregulation of inflammatory pathways premising the onset of PD. A family of inducible transcription factors, nuclear factor-κB (NF-κB), is found to show expression in various cells and tissues, such as microglia, neurons, and astrocytes which play an important role in activation and regulation of inflammatory intermediates during inflammation. Both canonical and non-canonical NF-κB pathways are involved in the regulation of the stimulated cells. During the prodromal/asymptomatic stage of age-associated neurodegenerative diseases (i.e., PD and AD), chronic neuroinflammation may act silently as the driver of neuronal dysfunction. Though research has provided an insight over age-related neurodegeneration in PD, elaborative role of NF-κB in neuroinflammation is yet to be completely understood and thus requires more investigation. Polyphenols, a group of naturally occurring compound in medicinal plants, have gained attention because of their anti-oxidative and anti-neuroinflammatory properties in neurodegenerative diseases. In this aspect, this review highlights the role of NF-κB and the possible therapeutic roles of polyphenols in NF-κB-mediated neuroinflammation in PD.

Indexed as

AnimalsAntiparkinson AgentsBrainEncephalitisHumansNeuronsNF-kappa BParkinson DiseasePolyphenolsReactive Oxygen SpeciesAntiparkinson AgentsNF-kappa BPolyphenolsReactive Oxygen SpeciesAstrocytesMicrogliaNeuroinflammationNF-κBOxidative stressParkinson’s disease

Identifiers

PMID31823227
OpenAlexW2993255052

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.