Evidence map›Paper›PMID 31823208›Full record

ReviewIndian journal of pediatrics2020

Laboratory Approach to Hemolytic Anemia.

Manu Jamwal, Prashant Sharma, Reena Das

Abstract readReview
PubMed Publisher
In one paragraph

Review in Indian journal of pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
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  4. Review
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  17. The diagnostic protocol for hereditary spherocytosis-2021 update.Journal of clinical laboratory analysis · 2021
    Review
  18. Article
  19. Article
  20. Iron Metabolism, Hemolytic Anemia, and Thalassemia.Indian journal of pediatrics · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Manu JamwalDepartment of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Prashant SharmaDepartment of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Reena DasDepartment of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. reenadaspgi@hotmail.com.ORCID http://orcid.org/0000-0002-8938-5423
Post Graduate Institute of Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hemolytic anemias are a group of disorders with varied clinical and molecular heterogeneity. They are characterized by decreased levels of circulating erythrocytes in blood. The pathognomic finding is a reduced red cell life span with severe anemia or, compensated hemolysis accompanied by reticulocytosis. The diagnostic workup or laboratory approach for hemolytic anemias is based on methodical step-wise testing which includes red blood cell morphology, hematological indices with increased reticulocyte count along with clinical features of hemolytic anemias. If conventional laboratory tests are unable to detect the underlying cause of hemolysis, genetic testing is recommended. Sanger sequencing along with conventional testing is the most efficient way to diagnose the underlying genetic causes, especially in thalassemias/hemoglobinopathies, if required. However, hemolytic anemias being highly heterogeneous disorders, next-generation sequencing-based screening is rapidly becoming an efficient way to decipher the etiologies where common causes have been excluded.

Indexed as

Anemia, HemolyticAnemia, Hemolytic, Congenital NonspherocyticClinical Laboratory TechniquesElliptocytosis, HereditaryErythrocytesGenetic TestingGlucosephosphate Dehydrogenase DeficiencyHematologic TestsHemoglobinopathiesHemoglobinuria, ParoxysmalHemolysisHigh-Throughput Nucleotide SequencingHumansPyruvate KinasePyruvate Metabolism, Inborn ErrorsReticulocyte CountPyruvate KinaseHemoglobinopathyHemolytic anemiaLaboratory investigationsRed cell disordersRed cell enzyme deficiencies

Identifiers

PMID31823208
OpenAlexW2992964808

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.