Evidence map›Paper›PMID 31823197›Full record

ArticleMolecular neurobiology2020

β-Catenin Role in the Vulnerability/Resilience to Stress-Related Disorders Is Associated to Changes in the Serotonergic System.

Emilio Garro-Martínez, Rebeca Vidal, Albert Adell, Álvaro Díaz, Elena Castro, Josep Amigó, Raquel Gutiérrez-Lanza, Eva Florensa-Zanuy, Laura Gómez-Acero, M Mark Taketo and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. 5-HTACS chemical neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Emilio Garro-MartínezCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Santander, Spain.ORCID http://orcid.org/0000-0001-8819-7503
Rebeca VidalCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Santander, Spain.ORCID http://orcid.org/0000-0002-3339-5681
Albert AdellCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Santander, Spain.ORCID http://orcid.org/0000-0003-0570-4931
Álvaro DíazCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Santander, Spain.ORCID http://orcid.org/0000-0002-8783-4555
Elena CastroCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Santander, Spain.ORCID http://orcid.org/0000-0002-6750-5519
Josep AmigóInstituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria-CSIC-SODERCAN, C/Albert Einstein, 22, 39011, Santander, Spain.
Raquel Gutiérrez-LanzaInstituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria-CSIC-SODERCAN, C/Albert Einstein, 22, 39011, Santander, Spain.ORCID http://orcid.org/0000-0002-6260-1640
Eva Florensa-ZanuyCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Santander, Spain.ORCID http://orcid.org/0000-0001-5045-7680
Laura Gómez-AceroInstituto de Biomedicina y Biotecnología de Cantabria (IBBTEC), Universidad de Cantabria-CSIC-SODERCAN, C/Albert Einstein, 22, 39011, Santander, Spain.ORCID http://orcid.org/0000-0003-2107-2129
M Mark TaketoDivision of Experimental Therapeutics, Graduate School of Medicine, Kyoto University, Yoshida-Konoé-cho, Sakyo, Kyoto, 606-8501, Japan.ORCID http://orcid.org/0000-0002-9032-4505
Ángel PazosCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Santander, Spain.ORCID http://orcid.org/0000-0001-8047-8802
Fuencisla Pilar-CuéllarCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Santander, Spain. pilarmf@unican.es.ORCID http://orcid.org/0000-0003-1229-001X
Universidad de Cantabria · ESKyoto University · JPUniversidad Complutense de Madrid · ES

Funding

Centro de Investigación Biomédica en Red de Salud Mental CIBERSAM CB/07/09/0029Spanish Ministry of Economy and Competitiveness SAF2011-25020Spanish Ministry of Economy and Competitiveness SAF2015-67457-R MINECO/FEDER
6 · The paper itself

Abstract

We previously reported that the inactivation (cKO) or the stabilization (cST) of β-catenin in cells expressing the astrocyte-specific glutamate aspartate transporter (GLAST) is associated with the vulnerability or resilience to exhibit anxious/depressive-like behaviors, respectively, and to changes in hippocampal proliferation. Here, we used these cKO and cST β-catenin mice to study the serotonergic system functionality associated with their behavioral/molecular phenotype. The activity of 5-HT

Indexed as

AnimalsAnxietyBehavior, Animalbeta CateninCorticosteroneDepressionHippocampusMaleMicePrefrontal CortexReceptor, Serotonin, 5-HT1ASerotoninbeta CateninCorticosteroneCTNNB1 protein, mouseReceptor, Serotonin, 5-HT1ASerotonin5-HT 1A receptorSerotoninStressTransgenic miceβ-Catenin

Identifiers

PMID31823197
OpenAlexW2992918488

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.