ReviewJournal of assisted reproduction and genetics2020
Microbial contamination in assisted reproductive technology: source, prevalence, and cost.
Review in Journal of assisted reproduction and genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Procedure-specific environmental microbiological monitoring in IVF laboratories: the SMILE multicenter study.Journal of assisted reproduction and genetics · 2026Article
- Effects of vaginal microbiota onMicrobiology spectrum · 2025Article
- Characterization of cellular and molecular immune components of the painted white sea urchin Lytechinus pictus in response to bacterial infection.Immunology and cell biology · 2025Article
- A case of Massilia timonae identified during time-lapse ART cycles in a pre-implantation embryo.JBRA assisted reproduction · 2024Article
- Successful pregnancy with intracytoplasmic sperm injection after bacterial contamination of embryo culture in in vitro fertilization: a case report.Journal of medical case reports · 2024Article
- Zona pellucida removal resulted in a successful live birth: Report on a case with recurrent implantation failure due to embryonic bacteria contamination.Clinical case reports · 2024Article
- Effects of Embryo Microbial Contamination on ART and Neonatal Outcomes.Infection and drug resistance · 2024Article
- Spermbots and Their Applications in Assisted Reproduction: Current Progress and Future Perspectives.International journal of nanomedicine · 2024Review
- The microbiota: a key regulator of health, productivity, and reproductive success in mammals.Frontiers in microbiology · 2024Review
- IVF cycle safety when a positive passive air sampling occurs under laminar flow hood in absence of a detectable contamination in the embryo culture.Frontiers in cell and developmental biology · 2024Article
- Analysis of the clinical outcomes of microbial contamination caused by environmental contamination of the embryology laboratory during IVF-ET treatment cycles.BMC pregnancy and childbirth · 2023Article
- Bovine neonatal microbiome origins: a review of proposed microbial community presence from conception to colostrum.Translational animal science · 2023Article
- A new method to rescue embryos contaminated by bacteria.F&S reports · 2022Article
- Common practices among consistently high-performing in vitro fertilization programs in the United States: 10-year update.Fertility and sterility · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Even the strictest laboratories and clinics are prone to the occurrence of microbial contamination. In the case of in vitro fertilization (IVF) research and practice facilities, the number of possible sources is particularly vast. In addition to ambient air, personnel, and non-sterilized materials, follicular fluid and semen from patients are a very common gateway for a diverse range of bacteria and fungi into embryo cultures. Even so, reports of contamination cases are rare, what leads many clinics to see the issue as a negligible risk. Microbiological contamination may result in the demise of the patient's embryos, leading to additional costs to both the patient and the clinics. Regardless of financial loss, emotional costs, and stress levels during IVF are highly distressing. Other worrisome consequences include DNA fragmentation, poor-quality embryos, early pregnancy loss or preterm birth, and possible long-term damages that need further investigation. In this review, we aimed to shed a light on the issue that we consider largely underestimated and to be the underlying cause of poor IVF outcomes in many cases. We also discuss the composition of the microbiome and how its interaction with the reproductive tract of IVF-seeking patients might influence their outcomes. In conclusion, we urge clinics to more rigorously identify, register, and report contamination occurrences, and highlight the role of the study of the microbiome to improve overall results and safety of assisted reproduction.
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Registered trials
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