ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2020
Short-term effects of caffeine intake on anterior chamber angle and intraocular pressure in low caffeine consumers.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The trial behind it
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Acute Effects of Oral Caffeine Intake on Human Global-Flash mfERG Responses: A Placebo-Controlled, Double-Masked, Balanced Crossover Study.Investigative ophthalmology & visual science · 2024Trial
- Effects of caffeine intake on the biomechanical properties of the cornea: a placebo-controlled, double-blind, crossover pilot study in low caffeine consumers.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Trial
- Effect of caffeine on superficial retinal vasculature of the macula in high myopes using optical coherence tomography angiography - A pilot study.Journal of optometryTrial
- Diurnal Variations in Anterior and Posterior Corneal Thickness and Curvature in Healthy Eyes: Global and Sector-Based Metrics and Lifestyle Associations.Life (Basel, Switzerland) · 2026Article
- Acute intraocular pressure changes during isometric exercise in glaucoma patients: the influence of exercise and intensity.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- [Nutrition and dietary supplementation and glaucoma].Die Ophthalmologie · 2025Review
- The Immediate Effects of Different Types of Tea Consumption on Ocular Biometric and Specular Microscopic Parameters in Healthy Subjects.The Eurasian journal of medicine · 2025Article
- Towards modifying the genetic predisposition for glaucoma: An overview of the contribution and interaction of genetic and environmental factors.Molecular aspects of medicine · 2023Review
- Caffeine and Its Neuroprotective Role in Ischemic Events: A Mechanism Dependent on Adenosine Receptors.Cellular and molecular neurobiology · 2022Review
- Effect of Coffee on Lipopolysaccharide-Induced Immortalized Human Oral Keratinocytes.Foods (Basel, Switzerland) · 2022Article
- Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update.Nutrients · 2022Review
- Article
- Intraocular Pressure, Glaucoma, and Dietary Caffeine Consumption: A Gene-Diet Interaction Study from the UK Biobank.Ophthalmology · 2021Article
- Caffeine Intake Effects on Intraocular Pressure in Healthy and Glaucomatous Populations: A Systematic Review and Meta-Analysis.Journal of current ophthalmologyReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute caffeine consumption causes a transient increase in IOP; however, the mechanisms underlying this phenomenon remain unknown. This study aims to determine the structural changes in cornea and anterior chamber associated with caffeine ingestion.
methodsSeventeen healthy low caffeine consumers ingested a capsule of caffeine (~ 4 mg/kg) or placebo (300 mg of corn-starch) in a counterbalanced manner. We measured IOP by rebound tonometry and the anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA) and central corneal thickness (CCT) with the Pentacam rotating Scheimpflug camera. Subjective feelings of arousal were also obtained. All the dependent variables were obtained before and 30, 60 and 90 min after caffeine/placebo intake.
resultsCaffeine intake caused an acute IOP rise (p = 0.005, η
conclusionThe IOP rise associated with caffeine intake may be caused by an ACA reduction, which may add resistance to the outflow of aqueous humour. The current results may be of special relevance for subjects at high risk for glaucoma onset or progression and may help to understand the mechanisms underlying caffeine-induced ocular hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.