ArticleNature2019
The gene-based hack that is revolutionizing epidemiology.
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Androgen Deprivation Therapy Unrelated to Alzheimer's Disease in the UK Biobank Cohort.Anticancer research · 2023Pooled it
- Vitamin D Receptor Gene Polymorphisms and Risk of Alzheimer Disease and Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2021Pooled it
- Non-genetic risk and protective factors and biomarkers for neurological disorders: a meta-umbrella systematic review of umbrella reviews.BMC medicine · 2021Pooled it
- Can increasing years of schooling reduce type 2 diabetes (T2D)?: Evidence from a Mendelian randomization of T2D and 10 of its risk factors.Scientific reports · 2020Trial
- The rapid growth in Mendelian randomization studies.European journal of epidemiology · 2025Article
- A focusing framework for testing bi-directional causal effects in Mendelian randomization.Journal of the Royal Statistical Society. Series B, Statistical methodology · 2025Article
- GENIUS-MAWII: for robust Mendelian randomization with many weak invalid instruments.Journal of the Royal Statistical Society. Series B, Statistical methodology · 2024Article
- Two sample Mendelian Randomisation using an outcome from a multilevel model of disease progression.European journal of epidemiology · 2024Article
- Review
- The proliferation of derivative and redundant studies in endocrinology due to the application of Mendelian Randomisation and other methods to open databases.Frontiers in endocrinology · 2024Article
- Prediction of immune infiltration and prognosis for patients with gastric cancer based on the immune-related genes signature.Heliyon · 2023Article
- Integrating multi-omics summary data using a Mendelian randomization framework.Briefings in bioinformatics · 2022Article
- Identifying Novel Causes of Cancers to Enhance Cancer Prevention: New Strategies Are Needed.Journal of the National Cancer Institute · 2022Article
- Caution against examining the role of reverse causality in Mendelian Randomization.Genetic epidemiology · 2021Article
- IMI Risk Factors for Myopia.Investigative ophthalmology & visual science · 2021Review
- Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.Lancet (London, England) · 2020Article
- World-class athletic performance and genetic endowment.Nature metabolism · 2020Review
- The Use of Mendelian Randomization to Determine the Role of Metabolic Traits on Urinary Albumin-to-Creatinine Ratio.Diabetes · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
31822846What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.