Evidence map›Paper›PMID 31822818›Full record

ArticleMolecular psychiatry2021

Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome.

David W Greening, Michael Notaras, Maoshan Chen, Rong Xu, Joel D Smith, Lesley Cheng, Richard J Simpson, Andrew F Hill, Maarten van den Buuse

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. A Mechanistic Review on Toxicity Effects of Methamphetamine.International journal of medical sciences · 2025
    Review
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  10. Sex Differences in Psychosis: Focus on Animal Models.Current topics in behavioral neurosciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

David W Greening *Baker Heart and Diabetes Institute, Molecular Proteomics, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0001-7516-485X
Michael Notaras *Weill Cornell Medical College, Cornell University, New York, NY, USA.ORCID http://orcid.org/0000-0003-4026-8805
Maoshan ChenAustralian Centre for Blood Diseases (ACBD), Central Clinical School, Monash University, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-3827-4969
Rong XuDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-5510-3678
Joel D SmithBiological Research Unit, Racing Analytical Services Ltd, Flemington, VIC, Australia.
Lesley ChengDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-8075-6144
Richard J SimpsonDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0002-9834-0796
Andrew F HillDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0001-5581-2354
Maarten van den BuuseSchool of Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia. m.vandenbuuse@latrobe.edu.au.ORCID http://orcid.org/0000-0002-7555-3799
La Trobe University · AUAustralian Centre for HIV and Hepatitis Virology Research · AUBaker Heart and Diabetes Institute · AUCornell University · USRacing Victoria · AUThe University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methamphetamine (Meth) abuse has reached epidemic proportions in many countries and can induce psychotic episodes mimicking the clinical profile of schizophrenia. Brain-derived neurotrophic factor (BDNF) is implicated in both Meth effects and schizophrenia. We therefore studied the long-term effects of chronic Meth exposure in transgenic mice engineered to harbor the human BDNF

Indexed as

Amphetamine-Related DisordersBrain-Derived Neurotrophic FactorMethamphetaminePsychotic DisordersAnimalsGenotypeMicePolymorphism, Single NucleotideProteomeBdnf protein, mouseBrain-Derived Neurotrophic FactorMethamphetamineProteome

Identifiers

PMID31822818
OpenAlexW2994924370

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.