ArticleScientific reports2019
Advanced microscopy analysis of the micro-nanoscale architecture of human menisci.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Characterization of calcifications in posterior horn of human meniscus using micro-computed tomography.Osteoarthritis and cartilage open · 2026Article
- A translational approach to airway reconstruction leveraging decellularized meniscus and cartilage progenitor cells.Nature communications · 2026Article
- Structural Motifs in Soft Fibrous Tissues: Revealing Structure-Mechanics Relationships in Deformation and Tear Resistance for Biomimetic Material Design.Advanced healthcare materials · 2025Review
- Hybrid Hydrogels Augmented via Additive Network Integration (HANI) for Meniscal Tissue Engineering Applications.Gels (Basel, Switzerland) · 2025Article
- Structure-property relationships in fibrous meniscal tissue through image-based augmentation.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Article
- Mechanics of knee meniscus results from precise balance between material microstructure and synovial fluid viscosity.PloS one · 2025Article
- Finite element modeling of meniscal tears using continuum damage mechanics and digital image correlation.Scientific reports · 2023Article
- Region- and layer-specific investigations of the human menisci using SHG imaging and biaxial testing.Frontiers in bioengineering and biotechnology · 2023Article
- The Functionally Grading Elastic and Viscoelastic Properties of the Body Region of the Knee Meniscus.Annals of biomedical engineering · 2021Article
- High Resolution Micro-Computed Tomography Reveals a Network of Collagen Channels in the Body Region of the Knee Meniscus.Annals of biomedical engineering · 2021Article
- Quantitative three-dimensional collagen orientation analysis of human meniscus posterior horn in health and osteoarthritis using micro-computed tomography.Osteoarthritis and cartilage · 2021Article
- From meniscal resection to meniscal repair: a journey of the last decade.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complex inhomogeneous architecture of the human meniscal tissue at the micro and nano scale in the absence of artefacts introduced by sample treatments has not yet been fully revealed. The knowledge of the internal structure organization is essential to understand the mechanical functionality of the meniscus and its relationship with the tissue's complex structure. In this work, we investigated human meniscal tissue structure using up-to-date non-invasive imaging techniques, based on multiphoton fluorescence and quantitative second harmonic generation microscopy complemented with Environmental Scanning Electron Microscopy measurements. Observations on 50 meniscal samples extracted from 6 human menisci (3 lateral and 3 medial) revealed fundamental features of structural morphology and allowed us to quantitatively describe the 3D organisation of elastin and collagen fibres bundles. 3D regular waves of collagen bundles are arranged in "honeycomb-like" cells that are comprised of pores surrounded by the collagen and elastin network at the micro-scale. This type of arrangement propagates from macro to the nanoscale.
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