ArticleThe ISME journal2020
Exploration of the propagation of transpovirons within Mimiviridae reveals a unique example of commensalism in the viral world.
Article in The ISME journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 38 citations in OpenAlex.
- Rise of the viral giants: common themes underlying genome gigantism in eukaryotic viruses and bacteriophages.Current opinion in microbiology · 2026Review
- Pantanal virophage: a new virophage species associated with a moumouvirus and a transpoviron, expanding the genusJournal of virology · 2026Article
- Uncovering novel virophages and giant viruses in high-altitude Lake Namtso: diversity and evolution of host-virus-virophage tripartite interaction systems.Archives of microbiology · 2026Article
- Microalga-virus-virophage coculture reveals co-infection of multi-virophages with a giant virus.Archives of virology · 2026Article
- Conserved tripartite tail proteins mediate virophage-host interactions throughJournal of virology · 2025Article
- Twelfth scientific biennial meeting of the Australasian Virology Society: AVS12 2024.Journal of virology · 2025Article
- The final cut: how giant viruses of protists are released from their hosts' cells.Archives of virology · 2025Review
- 20 years of research on giant viruses.Npj viruses · 2025Review
- Pacmanvirus isolated from the Lost City hydrothermal field extends the concept of transpoviron beyond the family Mimiviridae.The ISME journal · 2025Article
- Complex transcriptional regulations of a hyperparasitic quadripartite system in giant viruses infecting protists.Nature communications · 2024Article
- The polinton-like supergroup of viruses: evolution, molecular biology, and taxonomy.Microbiology and molecular biology reviews : MMBR · 2024Review
- Are Viruses Taxonomic Units? A Protein Domain and Loop-Centric Phylogenomic Assessment.Viruses · 2024Review
- Natural history of eukaryotic DNA viruses with double jelly-roll major capsid proteins.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Natural history of eukaryotic DNA viruses with double jelly-roll major capsid proteins.bioRxiv : the preprint server for biology · 2024Article
- Virophages-Known and Unknown Facts.Viruses · 2023Review
- Updated Virophage Taxonomy and Distinction from Polinton-like Viruses.Biomolecules · 2023Article
- Giant virus biology and diversity in the era of genome-resolved metagenomics.Nature reviews. Microbiology · 2022Review
- The Astounding World of Glycans from Giant Viruses.Chemical reviews · 2022Review
- Designed Multifunctional Peptides for Intracellular Targets.Antibiotics (Basel, Switzerland) · 2022Review
- Viral Complexity.Biomolecules · 2022Review
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acanthamoeba-infecting Mimiviridae are giant viruses with dsDNA genome up to 1.5 Mb. They build viral factories in the host cytoplasm in which the nuclear-like virus-encoded functions take place. They are themselves the target of infections by 20-kb-dsDNA virophages, replicating in the giant virus factories and can also be found associated with 7-kb-DNA episomes, dubbed transpovirons. Here we isolated a virophage (Zamilon vitis) and two transpovirons respectively associated to B- and C-clade mimiviruses. We found that the virophage could transfer each transpoviron provided the host viruses were devoid of a resident transpoviron (permissive effect). If not, only the resident transpoviron originally isolated from the corresponding virus was replicated and propagated within the virophage progeny (dominance effect). Although B- and C-clade viruses devoid of transpoviron could replicate each transpoviron, they did it with a lower efficiency across clades, suggesting an ongoing process of adaptive co-evolution. We analysed the proteomes of host viruses and virophage particles in search of proteins involved in this adaptation process. This study also highlights a unique example of intricate commensalism in the viral world, where the transpoviron uses the virophage to propagate and where the Zamilon virophage and the transpoviron depend on the giant virus to replicate, without affecting its infectious cycle.
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