ArticleScientific reports2019
Gut Dysbiosis with Minimal Enteritis Induced by High Temperature and Humidity.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- High Humidity Exacerbates Rheumatoid Arthritis in Mice viaMicroorganisms · 2026Article
- High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue-Resident Memory T Cells via Altering Skin Microbiota.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Impact of Seasonal and Meteorological Factors on Microorganisms Present in Knee Joint Effusions Among Patients with Rheumatoid Arthritis.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Clinical efficacy and gut microbiota profiling by 16S rRNA sequencing in children with Henoch-Schönlein purpura treated with integrated Chinese and Western medicine.Frontiers in microbiology · 2026Article
- Heatwave exposure and gastrointestinal and liver diseases: complementary evidence from a population-based study and animal experiments.Frontiers in physiology · 2026Article
- Multi-omics analysis of the effects of fulvic acid on the growth performance of Larimichthys crocea in summer.Fish physiology and biochemistry · 2025Article
- Trehalose improves growth performance and gut health of yellow-feathered broilers exposed to heat stress.Tropical animal health and production · 2025Article
- The impact of climate, weather, seasonal transitions, and diurnal rhythms on gut microbiota and immune homeostasis.Antonie van Leeuwenhoek · 2025Review
- Impact of Relative Humidity on Heat Stress Responses in Early-Lactation Holstein Cows.Animals : an open access journal from MDPI · 2025Article
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- Integrating geospatial and environmental factors in colorectal cancer epidemiology: a regional study.Frontiers in public health · 2025Article
- Short-term exposure to a high-humidity environment triggers intestinal inflammation via AQP3.Frontiers in immunology · 2025Article
- The United European Gastroenterology green paper-climate change and gastroenterology.United European gastroenterology journal · 2024Review
- High temperature and humidity in the environment disrupt bile acid metabolism, the gut microbiome, and GLP-1 secretion in mice.Communications biology · 2024Article
- Prevalence, types, and risk factors of functional gastrointestinal diseases in Hainan Province, China.Scientific reports · 2024Article
- Intestinal microflora promotes Th2-mediated immunity through NLRP3 in damp and heat environments.Frontiers in immunology · 2024Article
- Climate change is not just global warming: Multidimensional impacts on animal gut microbiota.Microbial biotechnology · 2023Review
- Effects of high-/low-temperature and high-altitude hypoxic environments on gut microbiota of sports people: A retrospective analysis.Sports medicine and health science · 2023Review
- Gut microbiota mediated the effects of high relative humidity on lupus in female MRL/lpr mice.Advances in rheumatology (London, England) · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High temperature and humidity (HTH) can cause diarrhea owing to food and drinking water contamination. However, their direct effects on gut microbiota and gastrointestinal inflammation are unknown. This study aimed to investigate the effects of HTH and probiotics on the microbiome. Twenty-one male mice were randomly assigned to normal control (NC), HTH, and broad-spectrum probiotic-treated (PR) groups. HTH and PR groups were regularly housed at 30 ± 0.5 °C with humidity of 85-90% for eight consecutive weeks. A broad-spectrum probiotic was administrated to PR-group mice from day 50 to 56. Clinical signs were observed and gut microbiota were analyzed via 16 S rRNA-based functional metagenomics. Intestinal pathology and the expression of defensins and pro-inflammatory cytokines were also assessed. Mice in the HTH and PR groups gradually developed sticky or loose feces. The HTH group developed a distinct microbiota profile associated with augmented metabolism and human-like pathophysiologies upon suppression of environmental sensing. Pathological assays indicated minimal enteritis, increased bacterial translocation, and elevated intestinal pro-inflammatory cytokine levels. Thus, ambient HTH directly contributes to gut dysbiosis and minimal enteritis, whereas probiotics partially normalized the microbiota and ameliorated gut inflammation. This study provides novel insights into the pathogenesis of environment-associated diseases and offers a potential therapeutic approach.
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