ArticleScientific reports2019
Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Photodithazine-Mediated Antimicrobial Photodynamic Therapy: A Systematic Review of Efficacy and Applications.International journal of molecular sciences · 2025Pooled it
- Optical Coherence Tomography Angiography (OCTA) Captures Early Micro-Vascular Remodeling in Non-Melanoma Skin Cancer During Superficial Radiotherapy: A Proof-of-Concept Study.Diagnostics (Basel, Switzerland) · 2025Article
- Real-time mapping of photo-sono therapy induced cavitation using Doppler optical coherence tomography.Optics letters · 2024Article
- The LMIT: Light-mediated minimally-invasive theranostics in oncology.Theranostics · 2024Review
- Multimodal OCT Control for Early Histological Signs of Vulvar Lichen Sclerosus Recurrence after Systemic PDT: Pilot Study.International journal of molecular sciences · 2023Article
- High speed photo-mediated ultrasound therapy integrated with OCTA.Scientific reports · 2022Article
- An insight into photodynamic therapy towards treating major dermatological conditions.Journal of drug delivery science and technology · 2022Article
- Nonlinear Elasticity Assessment with Optical Coherence Elastography for High-Selectivity Differentiation of Breast Cancer Tissues.Materials (Basel, Switzerland) · 2022Article
- Bridging the macro to micro resolution gap with angiographic optical coherence tomography and dynamic contrast enhanced MRI.Scientific reports · 2022Article
- From Basic Mechanisms to Clinical Research: Photodynamic Therapy Applications in Head and Neck Malignancies and Vascular Anomalies.Journal of clinical medicine · 2021Review
- Red and blue light in antitumor photodynamic therapy with chlorin-based photosensitizers: a comparative animal study assisted by optical imaging modalities.Biomedical optics express · 2021Article
- Photodynamic Therapy for Basal Cell Carcinoma: The Clinical Context for Future Research Priorities.Molecules (Basel, Switzerland) · 2020Review
- Article
- Histological validation of in vivo assessment of cancer tissue inhomogeneity and automated morphological segmentation enabled by Optical Coherence Elastography.Scientific reports · 2020Article
- Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microvascular networks of human basal cell carcinomas (BCC) and surrounding skin were assessed with optical coherence angiography (OCA) in conjunction with photodynamic therapy (PDT). OCA images were collected and analyzed in 31 lesions pre-treatment, and immediately/24 hours/3-12 months post-treatment. Pre-treatment OCA enabled differentiation between prevalent subtypes of BCC (nodular and superficial) and nodular-with-necrotic-core BCC subtypes with a diagnostic accuracy of 78%; this can facilitate more accurate biopsy reducing sampling error and better therapy regimen selection. Post-treatment OCA images at 24 hours were 98% predictive of eventual outcome. Additional findings highlight the importance of pre-treatment necrotic core, vascular metrics associated with hypertrophic scar formation, and early microvascular changes necessary in both tumorous and peri-tumorous regions to ensure treatment success.
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