ArticleScientific reports2019
D-shaped plastic optical fibre aptasensor for fast thrombin detection in nanomolar range.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 69 citations in OpenAlex.
- Microfluidic-optical integrated portable platform with handheld pump for wash-free plasmonic detection of thrombin and SARS-CoV-2 spike protein.Microsystems & nanoengineering · 2026Article
- Toscana Virus Diagnosis via a Point-of-Care Tool Based on Disposable Optical Fiber Biosensors.Analytical chemistry · 2026Article
- Development of a portable device for the detection of anti-PEG antibodies in human plasma.Scientific reports · 2026Article
- Functionalization Techniques Empowering Optical Fiber Biosensors in Label-Free Cancer Biomarker Detection.Biosensors · 2025Review
- Nano-Phase Separation and Analyte Binding in Aptasensors Investigated by Nano-IR Spectroscopy.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- High sensitivity tapered fiber refractive index biosensor using hollow gold nanoparticles.Scientific reports · 2025Article
- Development of an Aptamer-Based QCM-D Biosensor for the Detection of Thrombin Using Supported Lipid Bilayers as Surface Functionalization.Biosensors · 2024Article
- Optical fiber surface plasmon resonance sensor using electroless-plated gold film for thrombin detection.Analytical and bioanalytical chemistry · 2024Article
- Immuno-SPR biosensor for the detection of Brucella abortus.Scientific reports · 2023Article
- A novel plasmonic optical-fiber-based point-of-care test for periodontal MIP-1α detection.iScience · 2023Article
- Innovative Photonic Sensors for Safety and Security, Part I: Fundamentals, Infrastructural and Ground Transportations.Sensors (Basel, Switzerland) · 2023Review
- Progress and Trends of Optical Microfiber-Based Biosensors.Biosensors · 2023Review
- Review
- An Optical Fiber Sensor for Uranium Detection in Water.Biosensors · 2022Article
- Cost-Effective Fiber Optic Solutions for Biosensing.Biosensors · 2022Review
- Relevance of the Spectral Analysis Method of Tilted Fiber Bragg Grating-Based Biosensors: A Case-Study for Heart Failure Monitoring.Sensors (Basel, Switzerland) · 2022Article
- SARS-CoV-2 spike protein detection through a plasmonic D-shaped plastic optical fiber aptasensor.Talanta · 2021Article
- On the Effect of Soft Molecularly Imprinted Nanoparticles Receptors Combined to Nanoplasmonic Probes for Biomedical Applications.Frontiers in bioengineering and biotechnology · 2021Article
- Recent Advances in Electrochemical Sensors for the Detection of Biomolecules and Whole Cells.Biomedicines · 2020Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of optical biosensors for the rapid and costless determination of clinical biomarkers is of paramount importance in medicine. Here we report a fast and low-cost biosensor based on a plasmonic D-shaped plastic optical fibre (POF) sensor derivatized with an aptamer specific for the recognition of thrombin, the target marker of blood homeostasis and coagulation cascade. In particular, we designed a functional interface based on a Self Assembled Monolayer (SAM) composed of short Poly Ethylene Glycol (PEG) chains and biotin-modified PEG thiol in ratio 8:2 mol:mol, these latter serving as baits for the binding of the aptamer through streptavidin-chemistry. The SAM was studied by X-ray Photoelectron Spectroscopy (XPS) analysis, static contact angle (CA), Surface Plasmon Resonance (SPR) in POFs, and fluorescence microscopy on gold surface. The optimized SAM composition enabled the immobilization of about 112 ng/cm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.