ArticleScientific reports2019
Formalin-induced and neuropathic pain altered time estimation in a temporal bisection task in rats.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 19 citations in OpenAlex.
- Medium Spiny Neurons Mediate Timing Perception in Coordination with Prefrontal Neurons in Primates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Targeting APE1/Ref-1 to alleviate formalin-induced pain and spinal neuro-inflammation in rats: a promising therapeutic approach.Frontiers in neuroscience · 2025Article
- Ganoderma tsuage promotes pain sensitivity in aging mice.Scientific reports · 2024Article
- Assessing cognitive biases induced by acute formalin or hotplate treatment: an animal study using affective bias test.Frontiers in behavioral neuroscience · 2024Article
- Antinociceptive effects of vitamin B-complex: A behavioral and histochemical study in rats.IBRO neuroscience reports · 2023Article
- Probing the processing of facial expressions in monkeys via time perception and eye tracking.Zoological research · 2023Article
- Water-soluble pristine CBMC musculoskeletal disorders · 2023Article
- α-Pinene Influence on Pulpal Pain-Induced Learning and Memory Impairment in Rats Via Modulation of the GABAA Receptor.Advanced biomedical research · 2022Article
- Effects of intrathecal and intracerebroventricular microinjection of kaempferol on pain: possible mechanisms of action.Research in pharmaceutical sciences · 2021Article
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4 authors at 1 institution in 1 country.
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Abstract
Time perception is an important ability that is related closely to humans' and animals' daily activities. It can be distorted by various emotional states. In human studies, experimental pain has been shown to prolong the perception of time. However, related animal studies are lacking. In this study, we used a temporal bisection task to investigate how acute inflammatory pain (induced by hind-paw formalin injection) and chronic neuropathic pain [induced by spinal nerve ligation (SNL)] affected time perception in rats. Rats were trained to recognize "short" (1200-ms) and "long" (2400-ms) anchor-duration pure tones and were rewarded for corresponding lever presses. During testing, rats perceived a series of intermediate-duration and anchor-duration pure tones, and selected levers corresponding to the "short" and "long" tones. After formalin injection, rats gave more "long" lever-press responses than after saline injection. The point of subjective equality after formalin injection also increased, suggesting that formalin-induced acute pain extended time perception. In contrast, rats that had undergone SNL gave fewer "long" lever-press responses compared with the sham surgery group. This animal study suggests that formalin-induced pain and neuropathic pain may have different effects on time perception.
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