Evidence map›Paper›PMID 31822724›Full record

ArticleScientific reports2019

A change in the zinc ion concentration reflects the maturation of insulin-producing cells generated from adipose-derived mesenchymal stem cells.

Shogo Ohta, Tetsuya Ikemoto, Yuma Wada, Yu Saito, Shinichiro Yamada, Satoru Imura, Yuji Morine, Mitsuo Shimada

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Optimizing Generation of Stem Cell-Derived Islet Cells.Stem cell reviews and reports · 2022
    Review
  6. Myocardial TRPC6-mediated ZnNature communications · 2022
    Article
  7. Article
  8. Zinc.Advances in food and nutrition research · 2021
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shogo OhtaDepartment of Digestive and Transplant Surgery, Tokushima University, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan.ORCID http://orcid.org/0000-0003-4266-7367
Tetsuya IkemotoDepartment of Digestive and Transplant Surgery, Tokushima University, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan. ikemoto.tetsuya@tokushima-u.ac.jp.ORCID http://orcid.org/0000-0001-9800-1359
Yuma WadaDepartment of Digestive and Transplant Surgery, Tokushima University, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan.ORCID http://orcid.org/0000-0002-5941-6866
Yu SaitoDepartment of Digestive and Transplant Surgery, Tokushima University, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan.
Shinichiro YamadaDepartment of Digestive and Transplant Surgery, Tokushima University, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan.
Satoru ImuraDepartment of Digestive and Transplant Surgery, Tokushima University, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan.
Yuji MorineDepartment of Digestive and Transplant Surgery, Tokushima University, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan.
Mitsuo ShimadaDepartment of Digestive and Transplant Surgery, Tokushima University, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The generation of insulin-producing cells (IPCs) from pluripotent stem cells could be a breakthrough treatment for type 1 diabetes. However, development of new techniques is needed to exclude immature cells for clinical application. Dithizone staining is used to evaluate IPCs by detecting zinc. We hypothesised that zinc ion (Zn

Indexed as

AdipocytesAnimalsBone Marrow CellsCell DifferentiationCells, CulturedDiabetes Mellitus, ExperimentalDithizoneGlucoseHumansInsulinInsulin-Secreting CellsMesenchymal Stem CellsStreptozocinZincDithizoneGlucoseInsulinStreptozocinZinc

Identifiers

PMID31822724
PMCPMC6904733

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.