ArticleNature communications2019
Metabolic balancing by miR-276 shapes the mosquito reproductive cycle and Plasmodium falciparum development.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 55 citations in OpenAlex.
- Metabolomic Changes Underpinning Permethrin Resistance in theACS measurement science au · 2026Article
- Immune-reproductive cross talk in mosquitoes: molecular pathways and energy homeostasis.Parasites & vectors · 2026Review
- PfApiAT2 is a proline transporter essential for the transmission of Plasmodium falciparum by the mosquito vector.Nature communications · 2026Article
- PfApiAT2 is a proline transporter essential for the transmission ofResearch square · 2026Article
- A novel role ofMicrobiology spectrum · 2026Article
- PfApiAT2 is a proline transporter essential for the transmission ofbioRxiv : the preprint server for biology · 2026Article
- Metabolomic changes underpinning permethrin resistance in thebioRxiv : the preprint server for biology · 2026Article
- MicroRNA response in insect salivary glands to plant virus infection.Journal of virology · 2025Article
- Avian malaria and the overlooked metabolic pathways underlying mosquitoRoyal Society open science · 2025Article
- Insights into miRNAs of the Stingless BeeNon-coding RNA · 2025Article
- Study of the Drug Resistance Function of Ivermectin-Resistance-Related miRNAs in Haemonchus contortus.Acta parasitologica · 2025Article
- Host 5-HT affects Plasmodium transmission in mosquitoes via modulating mosquito mitochondrial homeostasis.PLoS pathogens · 2024Article
- Additional blood meals increase sporozoite infection in Anopheles mosquitoes but not Plasmodium falciparum genetic diversity.Scientific reports · 2024Article
- Article
- Evolutionary modelling indicates that mosquito metabolism shapes the life-history strategies of Plasmodium parasites.Nature communications · 2023Article
- Current Status of Omics Studies Elucidating the Features of Reproductive Biology in Blood-Feeding Insects.Insects · 2023Review
- MicroRNA-989 targets 5-hydroxytryptamine receptor1 to regulate ovarian development and eggs production in Culex pipiens pallens.Parasites & vectors · 2023Article
- Exosomes Derived fromMicrobiology spectrum · 2023Article
- Non-coding RNAs identification and regulatory networks in pathogen-host interaction in the microsporidia congenital infection.BMC genomics · 2023Article
- Adipokinetic hormone signaling in the malaria vector Anopheles gambiae facilitates Plasmodium falciparum sporogony.Communications biology · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The blood-feeding behavior of Anopheles females delivers essential nutrients for egg development and drives parasite transmission between humans. Plasmodium growth is adapted to the vector reproductive cycle, but how changes in the reproductive cycle impact parasite development remains unclear. Here, we show that the bloodmeal-induced miR-276-5p fine-tunes the expression of branched-chain amino acid transferase to terminate the reproductive cycle. Silencing of miR-276 prolongs high rates of amino acid (AA) catabolism and increases female fertility, suggesting that timely termination of AA catabolism restricts mosquito investment into reproduction. Prolongation of AA catabolism in P. falciparum-infected females also compromises the development of the transmissible sporozoite forms. Our results suggest that Plasmodium sporogony exploits the surplus mosquito resources available after reproductive investment and demonstrate the crucial role of the mosquito AA metabolism in within-vector parasite proliferation and malaria transmission.
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