Evidence map›Paper›PMID 31822658›Full record

ArticleTranslational psychiatry2019

Chronic corticosterone administration induces negative valence and impairs positive valence behaviors in mice.

Andrew Dieterich, Prachi Srivastava, Aitesam Sharif, Karina Stech, Joseph Floeder, Samantha E Yohn, Benjamin A Samuels

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Effects of electroconvulsive shock on the function, circuitry, and transcriptome of dentate gyrus granule neurons.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Article
  4. Corticosterone accelerates behavioral inflexibility via plasticity-related gene expression in the dorsal striatum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  5. Anxiolytic Effects ofInternational journal of general medicine · 2026
    Article
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  16. Validation of a non-food or water motivated effort-based foraging task as a measure of motivational state in male mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Andrew DieterichNeuroscience Graduate Program, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA.
Prachi SrivastavaDepartment of Psychology, Behavioral and Systems Neuroscience Area, Rutgers, The State University of New Jersey, 152 Frelinghuysen Rd, Piscataway, NJ, 08854, USA.
Aitesam SharifDepartment of Psychology, Behavioral and Systems Neuroscience Area, Rutgers, The State University of New Jersey, 152 Frelinghuysen Rd, Piscataway, NJ, 08854, USA.
Karina StechDepartment of Psychology, Behavioral and Systems Neuroscience Area, Rutgers, The State University of New Jersey, 152 Frelinghuysen Rd, Piscataway, NJ, 08854, USA.
Joseph FloederDepartment of Psychology, Behavioral and Systems Neuroscience Area, Rutgers, The State University of New Jersey, 152 Frelinghuysen Rd, Piscataway, NJ, 08854, USA.ORCID http://orcid.org/0000-0002-6800-7730
Samantha E YohnDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.
Benjamin A SamuelsNeuroscience Graduate Program, Rutgers, The State University of New Jersey, Piscataway, NJ, 08854, USA. ben.samuels@rutgers.edu.ORCID http://orcid.org/0000-0003-2535-0376
Rutgers, The State University of New Jersey · USVanderbilt University · US

Funding

Molecular and Neural Circuitry Mechanisms Underlying Antidepressant Treatment ResistanceR01MH112861 · NIMH · RUTGERS, THE STATE UNIV OF N.J. · PI SAMUELS, BENJAMIN A · 2017 to 2021
$1.9M
NIMH NIH HHS R01 MH112861
6 · The paper itself

Abstract

Behavioral approaches utilizing rodents to study mood disorders have focused primarily on negative valence behaviors associated with potential threat (anxiety-related behaviors). However, for disorders such as depression, positive valence behaviors that assess reward processing may be more translationally valid and predictive of antidepressant treatment outcome. Chronic corticosterone (CORT) administration is a well-validated pharmacological stressor that increases avoidance in negative valence behaviors associated with anxiety

Indexed as

Disease Models, AnimalAnimalsAnxietyAvoidance LearningBehavior, AnimalCorticosteroneLearningMaleMiceMice, Inbred C57BLRewardSteroidsCorticosteroneSteroids

Identifiers

PMID31822658
PMCPMC6904464
OpenAlexW2994700128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.