Evidence map›Paper›PMID 31822602›Full record

ArticlemSystems2019

Environmental Chemical Diethylhexyl Phthalate Alters Intestinal Microbiota Community Structure and Metabolite Profile in Mice.

Ming Lei, Rani Menon, Sara Manteiga, Nicholas Alden, Carrie Hunt, Robert C Alaniz, Kyongbum Lee, Arul Jayaraman

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. The intestinal microbiota as mediators between dietary contaminants and host health.Experimental biology and medicine (Maywood, N.J.) · 2023
    Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Intestinal Microecology of Mice Exposed to TiOFoods (Basel, Switzerland) · 2022
    Article
  16. Article
  17. Article
  18. Impact of Contaminants on Microbiota: Linking the Gut-Brain Axis with Neurotoxicity.International journal of environmental research and public health · 2022
    Review
  19. Article
  20. The Impact of Di-Isononyl Phthalate Exposure on Specialized Epithelial Cells in the Colon.Toxicological sciences : an official journal of the Society of Toxicology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ming Lei *Department of Chemical and Biological Engineering, Tufts University, Medford, Massachusetts, USA.
Rani Menon *Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, Texas, USA.
Sara ManteigaDepartment of Chemical and Biological Engineering, Tufts University, Medford, Massachusetts, USA.
Nicholas AldenDepartment of Chemical and Biological Engineering, Tufts University, Medford, Massachusetts, USA.
Carrie HuntDepartment of Microbial Pathogenesis and Immunology, College of Medicine, Texas Health Science Center, Texas A&M University, College Station, Texas, USA.
Robert C AlanizDepartment of Microbial Pathogenesis and Immunology, College of Medicine, Texas Health Science Center, Texas A&M University, College Station, Texas, USA.
Kyongbum LeeDepartment of Chemical and Biological Engineering, Tufts University, Medford, Massachusetts, USA kyongbum.lee@tufts.edu arulj@mail.che.tamu.edu.
Arul JayaramanArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, Texas, USA kyongbum.lee@tufts.edu arulj@mail.che.tamu.edu.
Tufts University · USTexas A&M Health Science Center · USTexas A&M University · US

Funding

Computational Metabolomics of Gut Microbiota MetabolitesR21GM106251 · NIGMS · TUFTS UNIVERSITY MEDFORD · PI LEE, KYONGBUM · 2014 to 2015
$404k
A Machine-Learning Based Software Widget for Resolving Metabolite IdentitiesR03CA211839 · NCI · TUFTS UNIVERSITY MEDFORD · PI LEE, KYONGBUM · 2016 to 2016
$148k
NCI NIH HHS R03 CA211839NIGMS NIH HHS R21 GM106251
6 · The paper itself

Abstract

Exposure to environmental chemicals during windows of development is a potentially contributing factor in gut microbiota dysbiosis and linked to chronic diseases and developmental disorders. We used a community-level model of microbiota metabolism to investigate the effects of diethylhexyl phthalate (DEHP), a ubiquitous plasticizer implicated in neurodevelopmental disorders, on the composition and metabolite outputs of gut microbiota in young mice. Administration of DEHP by oral gavage increased the abundance of

Indexed as

autismmetabolomicsmicrobiotaphthalates

Identifiers

PMID31822602
PMCPMC6906742
OpenAlexW2994666918

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.