ArticlemSystems2019
Marine Metabolomics: a Method for Nontargeted Measurement of Metabolites in Seawater by Gas Chromatography-Mass Spectrometry.
Article in mSystems, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 4 citations in OpenAlex.
- Spatiotemporal and hydrodynamic influences on microbial and exometabolite dynamics in coral reef and seagrass ecosystems.The ISME journal · 2026Article
- Practical guide for marine exo-metabolomic sample preparation.The ISME journal · 2026Review
- Alkane-oxidizing consortia produce substantial amounts of disaccharides.Frontiers in microbiology · 2026Article
- Intracellular metabolomic profiling of Picochlorum sp. under diurnal conditions mimicking outdoor light, temperature, and seasonal variations.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Benzoyl Chloride Derivatization Advances the Quantification of Dissolved Polar Metabolites on Coral Reefs.Journal of proteome research · 2024Article
- Metabolomics-based analysis of the diatomMethodsX · 2024Article
- Systematic evaluation of benzoylation for liquid chromatography-mass spectrometry analysis of different analyte classes.Journal of chromatography. A · 2024Article
- Non-targeted metabolomics and pseudo-targeted lipidomics combined with gut microbes reveal the protective effects ofFrontiers in cellular and infection microbiology · 2024Article
- Progress and challenges in exploring aquatic microbial communities using non-targeted metabolomics.The ISME journal · 2023Review
- Article
- Prebiotic Synthesis of Aspartate Using Life's Metabolism as a Guide.Life (Basel, Switzerland) · 2023Article
- Fucoid brown algae inject fucoidan carbon into the ocean.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- An untargeted exometabolomics approach to characterize dissolved organic matter in groundwater of the Samail Ophiolite.Frontiers in microbiology · 2023Article
- Sugars dominate the seagrass rhizosphere.Nature ecology & evolution · 2022Article
- Symbiont Community Composition inApplied and environmental microbiology · 2022Article
- Microbial metabolites in the marine carbon cycle.Nature microbiology · 2022Review
- MetFish: a Metabolomics Pipeline for Studying Microbial Communities in Chemically Extreme Environments.mSystems · 2021Article
- Characterization of the Exometabolome ofFrontiers in microbiology · 2021Article
- Article
- Verrucomicrobia use hundreds of enzymes to digest the algal polysaccharide fucoidan.Nature microbiology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbial communities exchange molecules with their environment, which plays a major role in regulating global biogeochemical cycles and climate. While extracellular metabolites are commonly measured in terrestrial and limnic ecosystems, the presence of salt in marine habitats limits the nontargeted analyses of the ocean exometabolome using mass spectrometry (MS). Current methods require salt removal prior to sample measurements, which can alter the molecular composition of the metabolome and limit the types of compounds detected by MS. To overcome these limitations, we developed a gas chromatography MS (GC-MS) method that avoids sample altering during salt removal and that detects metabolites down to nanomolar concentrations from less than 1 ml of seawater. We applied our method (SeaMet) to explore marine metabolomes
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.