Evidence map›Paper›PMID 31822580›Full record

ArticleGut2020

USF1 defect drives p53 degradation during

Lionel Costa, Sébastien Corre, Valérie Michel, Krysten Le Luel, Julien Fernandes, Jason Ziveri, Gregory Jouvion, Anne Danckaert, Nicolas Mouchet, David Da Silva Barreira and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it, 116 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Lionel CostaUnit of Helicobacter Pathogenesis, Department of Microbiology, CNRS ERL6002, Institut Pasteur, Paris, France.
Sébastien CorreInstitut de Génétique et Développement, Université de Rennes 1, Rennes, France.
Valérie MichelUnit of Helicobacter Pathogenesis, Department of Microbiology, CNRS ERL6002, Institut Pasteur, Paris, France.
Krysten Le LuelUnit of Helicobacter Pathogenesis, Department of Microbiology, CNRS ERL6002, Institut Pasteur, Paris, France.
Julien FernandesUnit of Helicobacter Pathogenesis, Department of Microbiology, CNRS ERL6002, Institut Pasteur, Paris, France.
Jason ZiveriUnit of Helicobacter Pathogenesis, Department of Microbiology, CNRS ERL6002, Institut Pasteur, Paris, France.
Gregory JouvionUnit of Experimental Neuropathology, Department of Global Health, Institut Pasteur, Paris, France.
Anne DanckaertUtechS PBI-C2RT, Institut Pasteur, Paris, France.
Nicolas MouchetInstitut de Génétique et Développement, Université de Rennes 1, Rennes, France.
David Da Silva BarreiraUnit of Helicobacter Pathogenesis, Department of Microbiology, CNRS ERL6002, Institut Pasteur, Paris, France.
Javier TorresUnidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias, UMAE Pediatria, Instituto Mexicano del Seguro Social (IMSS), México city, Mexico.
Margarita CamorlingaUnidad de Investigación Médica en Enfermedades Infecciosas y Parasitarias, UMAE Pediatria, Instituto Mexicano del Seguro Social (IMSS), México city, Mexico.
Mario Milco D'EliosDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Laurence FietteUnit of Experimental Neuropathology, Department of Global Health, Institut Pasteur, Paris, France.
Hilde De ReuseUnit of Helicobacter Pathogenesis, Department of Microbiology, CNRS ERL6002, Institut Pasteur, Paris, France.
Marie-Dominique GalibertInstitut de Génétique et Développement, Université de Rennes 1, Rennes, France.
Eliette TouatiUnit of Helicobacter Pathogenesis, Department of Microbiology, CNRS ERL6002, Institut Pasteur, Paris, France etouati@pasteur.fr.ORCID 0000-0002-3450-1773
Centre National de la Recherche Scientifique · FRInstitut de génétique et de développement de Rennes · FRInstitut Pasteur · FRMexican Social Security Institute · MXUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objective

designHuman gastric epithelial cell lines were infected with

resultsIn vivo we revealed the dominant role of USF1 in protecting gastric cells against

conclusionOur data reveal that the depletion of USF1 and its de-localisation in the vicinity of cell membranes are essential events associated to the genotoxic activity of

Indexed as

CarcinogenesisGastric MucosaHelicobacter pyloriStomach NeoplasmsAnimalsCell LineDNA DamageGenomic InstabilityHelicobacter InfectionsHumansMiceProteasome Endopeptidase ComplexTumor Suppressor Protein p53UbiquitinationUpstream Stimulatory FactorsProteasome Endopeptidase ComplexTumor Suppressor Protein p53Upstream Stimulatory FactorsUSF1 protein, humanUsf1 protein, mouseDNA damagegastric cancergenetic instabilityhelicobacter pylori infectiononcogenes

Identifiers

PMID31822580
PMCPMC7456735
OpenAlexW2995834341

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.