ArticleeNeuro
Activation of Distinct Channelrhodopsin Variants Engages Different Patterns of Network Activity.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed.
- Iso-orientation bias of layer 2/3 connections unifies spontaneous, visually and optogenetically driven V1 dynamics.Nature communications · 2026Article
- Pallidothalamic Circuit-Selective Manipulation Ameliorates Motor Symptoms in a Rat Model of Parkinsonian.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Neuronal and synaptic adaptations underlying the benefits of deep brain stimulation for Parkinson's disease.Translational neurodegeneration · 2023Review
- Active Dendrites and Local Field Potentials: Biophysical Mechanisms and Computational Explorations.Neuroscience · 2022Review
- High-performance microbial opsins for spatially and temporally precise perturbations of large neuronal networks.Neuron · 2022Article
- Rhodopsins: An Excitingly Versatile Protein Species for Research, Development and Creative Engineering.Frontiers in chemistry · 2022Review
- Frequency-Specific Optogenetic Deep Brain Stimulation of Subthalamic Nucleus Improves Parkinsonian Motor Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Theoretical optimization of high-frequency optogenetic spiking of red-shifted very fast-Chrimson-expressing neurons.Neurophotonics · 2019Article
- Theoretical analysis of low-power fast optogenetic control of firing of Chronos-expressing neurons.Neurophotonics · 2018Article
- Article
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Authors and funding
2 authors.
Funding
Abstract
Several recently developed Channelrhodopsin (ChR) variants are characterized by rapid kinetics and reduced desensitization in comparison to the widely used ChR2. However, little is known about how varying opsin properties may regulate their interaction with local network dynamics. We compared evoked cortical activity in mice expressing three ChR variants with distinct temporal profiles under the CamKII promoter: Chronos, Chrimson, and ChR2. We assessed overall neural activation by measuring the amplitude and temporal progression of evoked spiking. Using γ-range (30-80 Hz) local field potential (LFP) power as an assay for local network engagement, we examined the recruitment of cortical network activity by each tool. All variants caused light-evoked increases in firing
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.