Evidence map›Paper›PMID 31822495›Full record

ArticleCancer research2020

Rare

Cassandra L Moyer, Jennifer Ivanovich, Jessica L Gillespie, Rachel Doberstein, Marc R Radke, Marcy E Richardson, Scott H Kaufmann, Elizabeth M Swisher, Paul J Goodfellow

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Article
  4. Article
  5. The Genetic and Molecular Analyses of Rare Candidate GermlineInternational journal of molecular sciences · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Skin cancer risk in hereditary mixed cancer syndromes.Hereditary cancer in clinical practice · 2025
    Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. A nine-gene signature as prognostic biomarker in gastric cancer by bioinformatics analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Cassandra L MoyerJames Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
Jennifer IvanovichDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana.
Jessica L GillespieJames Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
Rachel DobersteinJames Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
Marc R RadkeDivision of Gynecologic Oncology, University of Washington, Seattle, Washington.
Marcy E RichardsonDepartment of Clinical Genomics, Ambry Genetics, Aliso Viejo, California.
Scott H KaufmannDivision of Oncology Research, Mayo Clinic, Rochester, Minnesota.ORCID 0000-0002-4900-7145
Elizabeth M SwisherDivision of Gynecologic Oncology, University of Washington, Seattle, Washington.ORCID 0000-0003-2331-0434
Paul J GoodfellowJames Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio. paul.goodfellow@osumc.edu.
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · USUniversity of Washington · USAmbry Genetics (United States) · USIndiana University – Purdue University Indianapolis · USMayo Clinic · US

Funding

Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI Zhenkun Lou · 2009 to 2026
$37.0M
NCI NIH HHS P50 CA136393
6 · The paper itself

Abstract

Germline loss-of-function mutations in BRCA1 interacting protein C-terminal helicase 1 (BRIP1) are associated with ovarian carcinoma and may also contribute to breast cancer risk, particularly among patients who develop disease at an early age. Normal BRIP1 activity is required for DNA interstrand cross-link (ICL) repair and is thus central to the maintenance of genome stability. Although pathogenic mutations have been identified in

Indexed as

Genetic Predisposition to DiseaseAdultAgedAge of OnsetAllelesBreast NeoplasmsCohort StudiesDatasets as TopicDNA Mutational AnalysisFanconi Anemia Complementation Group ProteinsFemaleGene FrequencyGenetic TestingGerm-Line MutationHeLa CellsHigh-Throughput Nucleotide SequencingBRIP1 protein, humanFanconi Anemia Complementation Group ProteinsRNA Helicases

Identifiers

PMID31822495
PMCPMC8722358
OpenAlexW2995662151

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.